This is a two-by-two factorial, response-adaptive multi-center randomized controlled clinical trial that tests whether pediatric patients with severe PARDS randomized to supine versus prone positioning and to CMV versus HFOV exhibit more VFD over a 28-day period.
The study will use residual blood collected from clinical samples collected around the time of meeting study inclusion to identify subphenotypes of subjects with shared underlying protein biomarker profiles, correlate subphenotypes with PICU morality, and assess degree of overlap between subphenotypes and classical syndromic definitions.
The study aims to determine whether evaluation of respiratory epithelial cell gene expression and protein profiling of exhaled breath condensate can identify ARDS subtypes.
The LUng iNjury Group at Children's Hospital of Philadelphia is dedicated to advancing the care of children who have difficulty breathing, with a focus on hospitalized children with severe respiratory failure requiring mechanical ventilation.
The study goal is to risk stratify pediatric (Acute Respiratory Distress Syndrome) ARDS patients and to identify sub-phenotypes with shared biology in order to appropriately target therapies in future trials.
Dr. Nadir Yehya is interested in all aspects of mechanical ventilation and respiratory failure in children, including pre-clinical models, ventilator-induced lung injury, and acute respiratory distress syndrome.
