Gene Regulation

Dr. Ding is an attending physician with the Cancer Center at CHOP. As for her research, she works to discover oncogenic co-dependencies using genomics data with the goal to develop novel precision medicine techniques for children with cancer. She focuses on high-risk leukemias and computational biology.

Dr. Choi's research focuses on the role of RNA-binding proteins in the regulation of alternative splicing and how mutations in these factors contribute to cancer. He uses a combination of genetically-engineered models and high-throughput approaches to better understand how alternative splicing influences cellular function and to identify potential opportunities for therapeutic intervention.

Dr. Wells studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.