The study will use residual blood collected from clinical samples collected around the time of meeting study inclusion to identify subphenotypes of subjects with shared underlying protein biomarker profiles, correlate subphenotypes with PICU morality, and assess degree of overlap between subphenotypes and classical syndromic definitions.
The LUng iNjury Group at Children's Hospital of Philadelphia is dedicated to advancing the care of children who have difficulty breathing, with a focus on hospitalized children with severe respiratory failure requiring mechanical ventilation.
The Immunology and Infectious Disease Research Initiative will harness the depth and breadth of infectious disease and immunology research across Children’s Hospital of Philadelphia to become the global leader in the study of infectious disease, vaccinology, and immunology.
Jenny Bush, BSN, RN is the clinical research nurse lead of the Critical Care Medicine research team within the Department of Anesthesiology and Critical Care medicine.
Dr. Brad Lindell explains how the Junior Faculty Award allowed his lab to build a large multi-omics sepsis dataset that may help researchers identify novel proteomic signatures related to high-risk adverse events.
The NIH-funded study, PRESCRIBE, will help researchers understand how antibiotics affect organ function recovery and respiratory microbiota in children with sepsis.
The overall goal of the Lindell Lab is to leverage translational immunology to define “treatable traits” in pediatric sepsis patients which can inform novel approaches to precision immunomodulation.