CAR T Cells | CHOP Research Institute
 

CAR T Cells

Researchers Tap Into T Cells’ Natural Biology to Help Boost CAR T-Cell Therapy

Published on
Apr 10, 2024
in Cornerstone Blog
FOXO1 Protein Helps CAR T-cell Longevity, Effectiveness
Evan Weber, PhD, and a research team from CHOP and Stanford Medicine discovered that the protein FOXO1 plays a key role in regulating CAR T cells’ longevity and effectiveness.

BEAM-201

BEAM-201

The purpose of this study is to determine the safety and effectiveness of an experimental form of therapy, known as BEAM-201.

Scientists Target FLT3 Protein in New Approach for High-risk Childhood Leukemias

Published on
Sep 8, 2023
in Cornerstone Blog
Immunotherapy Target in Two High-risk Childhood Leukemias
Sarah K. Tasian, MD, received a $1 million grant to further her research into a novel immunotherapy for high-risk pediatric leukemias.

Allo CD7 CAR WU-CART-007

The purpose of this study is to determine the safety and tolerability of an experimental form of therapy, known as WU-CART-007 (“study drug”). 

CHOP Establishes the Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy

Published on
Mar 28, 2022
in Cornerstone Blog
New Center for Pediatric Cancer Immunotherapy
The Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy is a first-of-its-kind hub for pediatric Cancer Immunotherapy.

How Do CAR T-Cells Fare After One Decade?

Published on
Feb 3, 2022
in Cornerstone Blog
How Do CAR T-Cells Fare After One Decade?
Two patients infused with CAR T-cell therapy one decade ago remain in remission with detectable levels of cancer-fighting cells.

CHOP Researchers Elucidate Mechanism Behind Immunotherapy Resistance in B-ALL

Published on
Jan 24, 2022
in Cornerstone Blog
Researchers Find Mechanism of Treatment Resistance in B-ALL
Researchers identified aberrant splicing as a culprit behind treatment resistance in B-ALL.

Improving Outcomes in Pediatric Oncology: Q&A With Garrett Brodeur, MD

Published on
Jan 3, 2022
in Cornerstone Blog
Improving Outcomes in Pediatric Oncology
Congratulations to Garrett Brodeur, MD, recipient of the American Society of Pediatric Hematology/Oncology Distinguished Career Award.

STAT Wunderkind "Blazing New Trails:" Q&A With Mark Yarmarkovich, PhD

Published on
Dec 15, 2021
in Cornerstone Blog
Q&A With STAT Wunderkind Mark Yarmarkovich, PhD
Dr. Mark Yarmarkovich, PhD, a senior scientist at CHOP, is a 2021 STAT Wunderkind.

ADHD, Humanized CAR T-Cell, Obesity, Malaria, Fetal Surgery

Published on
Jul 9, 2021
in Cornerstone Blog
In the News
This week’s news roundup features new findings in youth suicide risk, CAR T-cell therapy, obesity rates during the pandemic, and more.