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CRISPR

In the News: Community-Driven Research, CRISPR, RNA Sequencing, Cover of the Year

Published on
Feb 3, 2023
in Cornerstone Blog
In the News
In this news roundup, we celebrate research tools new and old, from RNA sequencing to gene editing to the best tool of all: collaboration.

In the News: Featured Research, Tonsillectomy, Gene Therapy, CAR T-Cell Therapy

Published on
Jun 24, 2022
in Cornerstone Blog
In the News
This week’s In the News features endocrinology research, news on gene therapy in blood disorders, CAR T-cell therapy, and more.

“Encourage Diversity of Thought:” Q&A With Marco Carpenter, PhD, Diversity Fellow

Published on
Dec 20, 2021
in Cornerstone Blog
Q&A With Marco D. Carpenter, PhD, Diversity Fellow
Dr. Carpenter’s research seeks to better understand how environmental factors affect the origins of disease via epigenetic modifications.
Will Bailis, PhD
Will Bailis

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

E-mail:
bailisw [at] chop.edu

Snapshot Science: What is PU.MA, a New Disease Discovered by CHOP Scientists?

Published on
May 24, 2021
in Cornerstone Blog
Snapshot Science: What is PU.MA?
A previously unreported immunodeficiency disease prevents the formation of the B cells and antibodies that help fight off infections.

Shalem Laboratory

Shalem Lab

The lab focuses on translational target discovery for a range of neurodegenerative diseases. We combine technology development of large-scale CRISPR-based perturbation screens with application of such technology together with additional genomic approaches.

Gadue Laboratory

Gadue Lab

The Gadue Lab studies human pancreatic and hematopoietic development and associated diseases using human pluripotent stem cells. The lab’s research efforts are devoted to directed differentiation and CRISPR-based genome engineering of stem cells to use in the study and development of treatments for diabetes and blood disorders.

Bailis Laboratory

Bailis Laboratory

All biological processes operate under biochemical constraints. The Bailis Lab aims to understand how metabolism controls the development and functional differentiation of the hematopoietic system by setting the biochemical potential of cells and tissues, using in vitro and in vivo CRISPR screening in primary immune cells.

CHOP Scientists Enlist CRISPR to Learn How to Disrupt SARS CoV-2’s Entry Routes

Published on
May 20, 2020
in Cornerstone Blog
CRISPR Screening for COVID-19
A CHOP scientist is leveraging her expertise in CRISPR-based genetic screens to contribute to our understanding of COVID-19’s pathology.

NIH Innovator Award Fuels New Tools for High Throughput Target Discovery

Published on
Mar 11, 2020
in Cornerstone Blog
Dr. Ophir Shalem
With a new NIH Innovator Award, Ophir Shalem, PhD, is developing an improved genetic screening method that directly targets proteins.