Proteomics | CHOP Research Institute
 

Proteomics

Published on
Nov 6, 2025
Meet Lynn Spruce, Technical Director of CHOP-Penn Proteomics Core, in this latest installment of the Q&A series called Tour the Cores.
Published on
Aug 8, 2023
Two CHOP researchers receive the Individual Biomedical Research Award from the Hartwell Foundation, which will fund early-stage, innovative projects.

The Single Cell Technology Core specializes in state-of-the-art single cell technologies and the analysis of complex data sets. We facilitate transcriptomic, epigenomic, and spatial-omic experiments.

The Weitzman Lab studies host responses to viral infections and the cellular environments viruses encounter and manipulate using biochemistry, molecular biology, genetics, and cell biology.

The research objectives of the Ischiropoulos Lab are to elucidate the nitric oxide signaling pathways at the proteome level in the cardiovascular and neuronal systems; define the molecular mechanisms by which nitric oxide signaling regulates metabolic pathways during development and aging; and develop and test novel therapeutics for long-chain f

The CHOP-Penn Proteomics Core provides a variety of protein and proteomics services for investigators at Children’s Hospital of Philadelphia, University of Pennsylvania, and outside institutions.

Dr. Ischiropoulos's research objectives are to develop and test novel therapeutics for long-chain fatty acid oxidation (LCFA) disorders, a collection of inherited metabolic diseases that affect the heart, liver and muscle. A second area of interest is the resolution of the nitric oxide signaling pathways at the proteome level in the cardiovascular and neuronal systems.

E-mail:
ischirop [at] pennmedicine.upenn.edu

Dr. Diskin's research is focused on translational genomics in childhood cancers. Her laboratory seeks to identify the genetic basis of childhood cancers by combining quantitative computational methods with rigorous "wet-lab" experimental approaches. In parallel, she has developed, and is applying, a proteogenomic approach to identify novel immunotherapeutic targets for high-risk and relapsed pediatric malignancies.

E-mail:
diskin [at] chop.edu