Lysosomes | CHOP Research Institute

Marks Laboratory

The Marks Lab aims to dissect the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles and the assembly, delivery, and function of their contents, and to understand how these processes are impacted by genetic diseases.

Cornerstone Blog

Identifying Genetic Variants Associated With Skin Pigmentation May Offer Disease Insight

Published on

Nov 11, 2020

Michael Marks, PhD, seeks to identify the genetic basis of normal human skin pigment variation, which could offer disease insight.

Cornerstone Blog

Grant Awarded to Study Gene Therapy for Disorders With Severe Brain Disease

Published on

Dec 4, 2019

John Wolfe, VMD, PhD, is studying gene therapy methods to correct the brain disease of lysosomal storage disorders.

John Wolfe, VMD, PhD, receives grant to study gene therapy treatment for lysosomal storage disorders with severe disease of the brain.

Michael S. Marks, PhD

Dr. Marks investigates the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles; the assembly, delivery and function of their contents; and how these processes are impacted by genetic diseases.

E-mail:

marksms [at] chop.edu

Naiara Akizu, PhD

Dr. Akizu’s research focuses on genetic and epigenetic mechanisms of neurodevelopmental disorders and pediatric neurodegeneration, with the specific goals of uncovering particularities mechanisms that provide diversity to the human brain and to uncover novel disease mechanisms and therapeutic options.

E-mail:

aquizun [at] chop.edu