This is a two-by-two factorial, response-adaptive multi-center randomized controlled clinical trial that tests whether pediatric patients with severe PARDS randomized to supine versus prone positioning and to CMV versus HFOV exhibit more VFD over a 28-day period.
Gastrointestinal motility disorders (GMD) and disorders of gut brain interactions (DGBI) include a wide spectrum of disease conditions, and it's relatively common in the general population.
The study will use residual blood collected from clinical samples collected around the time of meeting study inclusion to identify subphenotypes of subjects with shared underlying protein biomarker profiles, correlate subphenotypes with PICU morality, and assess degree of overlap between subphenotypes and classical syndromic definitions.
The LUng iNjury Group at Children's Hospital of Philadelphia is dedicated to advancing the care of children who have difficulty breathing, with a focus on hospitalized children with severe respiratory failure requiring mechanical ventilation.
Learn about a technique to analyze large datasets, preclinical results that show safety and efficacy of a drug that could help children with high-risk neuroblastoma, and a milestone in the CORSICA project that seeks to cure rare sinonasal cancers.
The goal of this study is to collect biological samples and medical information from children to create a Neuroscience Biorepository to advance future neurological research.
This study involves the collection of medical information and samples from people with a confirmed or suspected leukodystrophy or related disorder affecting the white matter of the brain, as well as "healthy controls" who are not known to be affected by one of these disorders.
