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Yael P. Mossé, MD
Professor of Pediatrics, Patricia Brophy Endowed Chair in Neuroblastoma Research
Dr. Mossé is a physician scientist who has focused on the childhood cancer neuroblastoma with the dual goals of improving patient outcomes and using the disease as a model to understand cancer in general. Her research discoveries have positioned ALK is the only mutated oncogene tractable for targeted therapy in NB.
Bio
Dr. Mossé is a physician scientist who has focused on the childhood cancer neuroblastoma with the dual goals of improving patient outcomes and using the disease as a model to understand cancer in general. Her seminal discovery of gain-of-function mutations of the Anaplastic Lymphoma Kinase (ALK) gene as the major cause of hereditary neuroblastoma, and the demonstration that these same alterations are the most common mutations in the sporadic forms of the disease have positioned ALK is the only mutated oncogene tractable for targeted therapy in NB. This provides the impetus for the long-term goal of her research program to develop novel therapeutic strategies aimed, in part, at effectively inhibiting ALK-mediated signaling in neuroblastoma and other ALK-driven or ALK-expressing childhood cancers. Her research program is now striving to leverage targeted protein degradation to target the five essential oncoproteins that drive the growth of childhood solid tumors. As the leader of the Neuroblastoma Developmental Therapeutics Program, she fosters collaboration across disciplines to translate genomic discoveries into clinical practice, providing hope and innovative therapies for vulnerable patients from around the world.
Education and Training
BA, Smith College (Literature), 1993
MD, Sackler School of Medicine, Tel Aviv, 1997
Fellowship, Children's Hospital of Philadelphia (Hematology/Oncology), 2003
Titles and Academic Titles
Professor of Pediatrics
Division of Oncology
University of Pennsylvania Perelman School of Medicine
Professional Memberships
American Society of Clinical Investigation, 2012
American Society of Clinical Oncology, 2013
American Association for Cancer Research, 2021
American Pediatric Society, 2021
Professional Awards
Young Investigator Award, American Society of Clinical Oncology, 2003
Career Development Award, American Society of Clinical Oncology, 2004
Foerderer-Murray Award, Children's Hospital of Philadelphia, 2006
First Inaugural James B. Nachman Junior Faculty Award in Pediatric Oncology, American Society of Clinical Oncology, 2012
Election to Membership, American Society of Clinical Investigation, 2012
First Inaugural James B. Nachman ASCO Junior Faculty Award in Pediatric Oncology, American Society of Clinical Oncology, 2012
Leadership Development Program, American Society of Clinical Oncology, 2013
ASCO Leadership Development Program, American Society of Clinical Oncology, 2013
Patricia Brophy Endowed Chair in Neuroblastoma Research, The Children's Hospital of Philadelphia/Alex's Lemonade Stand Foundation, 2018
Elected Member, American Pediatric Society, 2021
Frank A. Oski Memorial Award, American Society of Pediatric Hematology/Oncology, 2022
Dr. Audrey E. Evans Award of Excellence to Drs. John Maris and Yael Mossé, 2024
William Osler Patient Oriented Research Award, University of Pennsylvania Perelman School of Medicine, 2024
Publication Highlights
PubMed:
Sci Transl Med · March, 2019
Cancer Discov · January, 2016
Cancer Cell · November, 2014
Sci Transl Med · November, 2011
Nature · October, 2008