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senguptas [at]
Location - People View
11th Floor, 1103

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Shaon Sengupta, MBBS, MPH
Shaon Sengupta
Attending Neonatologist

Dr. Sengupta is a neonatologist and physician scientist with a long-standing interest in lung health. She studies the mechanisms of circadian regulation of lung inflammation, injury, and repair; and the effect of early life exposures on development and function of pulmonary circadian networks in adulthood.



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Dr. Sengupta's research interests focus on two main areas:

Determining the mechanisms of the circadian regulation of lung inflammation, injury and repair/regeneration: In particular, Dr. Sengupta's Lab is exploring the role of NK cells in mediating extensive immune-pathology when the clock is disrupted. Another project in the lab pertains to the effect of clock disruption of lung repair.

Effect of early life exposures on the development (or maldevelopment) and function of pulmonary circadian networks in adulthood: Using a neonatal hyperoxia model, Dr. Sengupta's Lab is exploring the deficits seen at various levels that persist into adulthood. Circadian rhythms can thus prove to be a novel therapeutic avenue for these long-standing effects of early life exposures.

Education and Training

MBBS, All India Institute of Medical Sciences, Medicine, 2006

MPH, Johns Hopkins Bloomberg School of Public Health, 2008

Pediatrics Residency, University at Buffalo, 2011

Neonatal-Perinatal Medicine Fellowship, Children's Hospital of Philadelphia, 2014

Titles and Academic Titles

Attending Neonatologist

Assistant Professor

Professional Memberships

Associate Scientific Advisor, Science Translational Medicine, 2020-

Member, American Physiological Society, 2018-

Adhoc reviewer for Science Translational Medicine, Scientific Reports, Cell Reports, International Archives of Allergy and Immunology, Allergy, The Journal of Neurochemistry, Respiratory Research, The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2015-

American Association of Immunologists, 2015-

Member, Society of Research on Biological Rhythms, 2013-

American Thoracic Society, 2012-

Professional Awards

FOCUS OID award for attending the “Early Career Women Faculty Leadership Development Seminar” organized by the AAMC, 2019

American Association of Immunologist (AAI) Travel Award for ECI conference, 2018

Annual Neonatal Cardiopulmonary Biology Young Investigators Forum Research Grant, 2017

Parker B. Francis Fellowship Research Opportunity Award, 2017

Best Poster Award, Translational Chronobiology Symposium 2015, Philadelphia, 2015

Department of Pediatrics Child Health Research Career Development Award (K12), 2015

American Academy of Pediatrics, National Conference & Exhibition Travel Award Recipient, 2013

AAP Resident Research Grant, 2009

Thomas P. Frawley Research Fellowship, University at Buffalo, 2009

Publication Highlights

Sun Y, Felt S, Jozwik A, Paras A, Habib MI, Anderson L, Feemster K, Cárdenas AM, Hartert T, Sengupta S, Chiu C, Lopez, CB.. Detection of defective viral genomes in nasal secretions predicts RSV disease severity in children and adults. Nat Microbiol. 2021 May; 6(5):672-681. PMID: 33795879
Issah Y, Naik A, Tang SY, Forrest K, Brooks TG, Lahens N, Theken KN, Sehgal A, Worthen GS, FitzGerald GA, Sengupta S.. Loss of Circadian Protection in Adults Exposed to Hyperoxia as Neonates. Elife. 2021 Mar; 10:e61241.PMID: 33650487
Sengupta S, Brooks TG, Grant GR, FitzGerald GA.. Accounting for Time: Circadian Rhythms in the Time of COVID-19. J Biol Rhythms. 2021 Feb; 36(1):4-8. PMID: 32875944
Hudock KM, Collins MS, Imbrogno M, Snowball J, Kramer EL, Brewington JJ, Gollomp K, McCarthy C, Ostmann AJ, Kopras EJ, Davidson CR, Srdiharan A, Arumugam P, Sengupta S, Xu Y, Worthen GS, Trapnell, BC, Clancy JP. Neutrophil Extracellular Traps Activate IL-8 and IL-1 Expression in Human Bronchial Epithelia. Am J Physiol Lung Cell Mol Physiol. 2020 Mar; PMID: 32159969
Haspel JA, Anafi R, Brown MK, Cermakian N, Depner C, Desplats P, Gelman AE, Haack M, Jelic S, Kim BS, Laposky AD, Lee YC, Mongodin E, Prather AA, Prendergast B, Reardon C, Shaw AC, Sengupta S, Szentirmai É, Thakkar M, Walker WE, Solt LA. Perfect timing: circadian rhythms, sleep and immunity - an NIH workshop summary. JCI Insight. 2020 Jan; 5(1): e131487. PMID: 31941836

Active Grants/Contracts

Role of Circadian Clock in Lung Inflammation
Principal Investigator

Replication of Defective Viral Genomes on Respiratory Syncytial Virus pathogenesis in Humans