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E-mail
camire [at] email.chop.edu
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Location - People View
Room 5018

3501 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Rodney M. Camire, PhD
Rodney M. Camire Headshot
Investigator

Dr. Camire's research focuses on understanding the components of the blood coagulation system, how they interface with activated cells, and how disturbances in their function lead to bleeding and thrombosis. He is also interested in developing novel therapeutic approaches (protein, gene-based, small molecule) to mitigate these events, which are major causes of morbidity and mortality worldwide.

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Bio

Dr. Camire is interested in understanding the components of the blood coagulation system, how they interface with activated cells, and how disturbances in their function lead to bleeding and thrombosis. His group is developing therapeutic approaches to mitigate these events, which are major causes of morbidity and mortality worldwide.

His current areas of investigation include understanding how clotting factor cofactors work, such as factor V and VIII, and defining their mechanism of activation. Dr. Camire's lab uncovered surprising observations that have fundamentally shifted current thinking about FV activation and its regulation by tissue factor pathway inhibitor.

Dr. Camire investigates structural correlates of protease function-basic and translational research to understand how processing of inactive serine protease zymogens, such as FX and FIX, to their active forms contribute to the expression of binding sites critical to their function. Knowledge from these biochemical studies has been applied to translational studies to develop novel protein therapeutics to treat bleeding in hemophilia, trauma, or other conditions.

Other current areas of investigation include imaging coagulation reactions. Dr. Camire uses fluorescence approaches developed for physical studies of coagulation enzyme function to develop enabling technologies that permit quantitative measurements of enzyme complex assembly and function in vivo. He also employs protein, gene therapy, and other strategies to alleviate hemophilia A or B. Using different bioengineering strategies, he aims to modify FVIII or FIX with unique properties that could be useful in a gene-based approach.

Dr. Camire has been funded from the NIH since 2003 and has published over 70 primary and review articles related to blood coagulation, and work from his laboratory has led to over 15 patents. Dr. Camire is a recent International Society on Thrombosis and Haemostasis Biennial Awards for Contributions to Hemostasis awardee, and he also sits on the Editorial Board of Blood.

Education and Training

BA, Saint Anslem College (Biochemistry), 1994

PhD, University of Vermont (Biochemistry), 1998

Fellowship, Children's Hospital of Philadelphia (Biochemistry), 2001

Titles and Academic Titles

Investigator

Professor of Pediatrics

Children’s Hospital of Philadelphia Endowed Chair in Pediatric Hematology

Professional Memberships

American Association for the Advancement of Science, 1998-

The American Society of Hematology, 2001-

American Heart Association, 2006-

International Society of Thrombosis and Hemostasis, 2006-

North American Society of Thrombosis and Hemostasis, 2013-

The American Society of Hematology, Scientific Committee on Hemostasis, 2014-2017

Professional Awards

Young Investigator Award, Annual Meeting of the American Society of Hematology, 2000, 2001

Young Investigator Award, International Society on Thrombosis and Haemostasis, 2001, 2005

American Heart Association (Penn/Del) Research Award, 2003

Early Career Investigator Award, The Bayer Hemophilia Awards Program, Bayer Corp., 2005

Copernicus Visiting Scientist, IUSS-Ferrara 1391, University of Ferrara, Ferrara, Italy, 2009

Alumni Academic Achievement Award, Saint Anselm College, 2009

Martin Villar Haemostasis Award (1st Prize), 2012

Publication Highlights

Camire RM. Rethinking events in the haemostatic process: role of factor V and TFPI. Haemophilia. 2016 Jul; 22 Suppl 5:3-8. PubMed [journal]PMID: 27405668
Ivanciu L, Krishnaswamy S, Camire RM. New insights into the spatiotemporal localization of prothrombinase in vivo. Blood. 2014 Sep; 124(11):1705-14. PubMed [journal]PMID: 24869936 PMCID: PMC4162104
Bunce MW, Bos MH, Krishnaswamy S, Camire RM. Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides. J Biol Chem. 2013 Oct; 288(42):30151-60. PubMed [journal]PMID: 24014022 PMCID: PMC3798483
Ivanciu L, Toso R, Margaritis P, Pavani G, Kim H, Schlachterman A, Liu JH, Clerin V, Pittman DD, Rose-Miranda R, Shields KM, Erbe DV, Tobin JF, Arruda VR, Camire RM. A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia. Nat Biotechnol. 2011 Oct; 29(11):1028-33. NIHMSID: NIHMS323371. PubMed [journal]PMID: 22020385 PMCID: PMC4157830

Links of Interest