In This Section

Contact
E-mail
bagatellr [at] email.chop.edu
Phone
Location - People View
Room 4022

3501 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Rochelle Bagatell, MD
Rochelle Bagatell
Solid Tumor Section Chief

Dr. Bagatell’s research focuses on improving therapies for children with neuroblastoma. She leads clinical research studies designed to critically evaluate current therapies for children with high-risk and relapsed disease, and is committed to conducting studies of new therapies for this population. She is currently pursuing research designed to evaluate biomarkers for response to targeted therapy in children with high-risk disease.

AddtoAny
Share:

Bio

Dr. Bagatell’s research is focused on the development and evaluation of new treatments for children with neuroblastoma. She has been integrally involved in several prospective clinical trials through the Children’s Oncology Group (COG), a cooperative group comprised of over 240 pediatric oncology centers. After chairing the COG Phase II trial of irinotecan and temozolomide in patients with relapsed neuroblastoma (ANBL0421), she serves as mentoring vice chair for a subsequent randomized Phase II trial evaluating the addition of targeted agents to the irinotecan/temozolomide backbone (ANBL1221). The exciting findings from this study were recently published in Lancet Oncology.

During this time Dr. Bagatell also chaired the high-risk task force within the COG Neuroblastoma Committee, and was involved in two pilot studies for newly diagnosed patients (ANBL09P1, ANBL12P1). The results of these studies informed the development of the next large-scale Phase III randomized study for newly diagnosed patients with high-risk disease (ANBL1531). She serves as the chair of this trial, a five-arm study that will enroll up to 800 patients to address the most pressing therapeutic and translational questions in the field at the present time.

As vice chair of the COG Neuroblastoma Committee, Dr. Bagatell is involved in the development of additional trials, including a frontline study for patients with low and intermediate risk disease as well as studies for patients with minimal residual disease following stem cell transplantation, and for those with relapsed/refractory disease. Furthermore, she is integrally involved in translational studies accompanying these trials, with a goal of identifying biomarkers to guide future therapeutic decision-making.
 

Education and Training

BA, Brown University (American History), 1987

MD, University of Arizona, 1993

Fellowship, University of Arizona (Pediatric Hematology/Oncology), 1999

Titles and Academic Titles

Solid Tumor Section Chief

Attending Physician

Associate Professor of Pediatrics

Publication Highlights

Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D. Revisions to the International Neuroblastoma Response Criteria (INRC): A Consensus Statement from the NCI-Clinical Trials Planning Meeting. J Clin Oncol. 2017 Aug; 35(22):2580-2587. PMID: 28471719
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin B, Parisi MT, Servaes S, Diccianni MB, Sondel PM, Maris JM, Park JR, Bagatell R. Randomised Phase II Trial of Irinotecan/Temozolomide (I/T) with Temsirolimus (TEM) or Dinutuximab (DIN) in Children with Refractory or Relapsed Neuroblastoma: A Report from the Children’s Oncology Group (COG). Lancet Oncol. 2017 Jul; 18(7):946-957. PMID: 28549783
Bagatell R, McHugh K, Naranjo A, Van Ryn C, Kirby C, Brock P, Lyons KA, States LJ, Rojas Y, Miller A, Volchenboum SL, Simon T, Krug B, Sarnacki S, Valteau-Couanet D, von Schweinitz D, Kammer B, Granata C, Pio L, Park JR, Nuchtern J. Assessment of Primary Site Response in Children with High-Risk Neuroblastoma: An International Multi-Center Study. J Clin Oncol. 2016 Mar; 34(7):740-6. PMID: 26755515
Bagatell R, London WB, Wagner LM, Voss S, Stewart C, Maris JM, Kretschmar C, Cohn SL. Phase II Study of Irinotecan and Temozolomide in Children with Relapsed or Refractory Neuroblastoma: A Children’s Oncology Group Study. J Clin Oncol. 2011 Jan; 29(2):208-13. PMID: 21115869