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Narasaiah Kovuru’s research focuses on understanding the origins of hematopoietic failure/bone marrow failure in Fanconi Anemia working with the murine model.
Narasaiah Kovuru, PhD, joined the Kurre Laboratroy in October 2021. His research focuses on understanding Fanconi Anemia (FA) pathway's importance in maintaining the hematopoietic stem cells (HSC) fitness.
FA is classically known to safeguard the genome during DNA replication, fork migration, genome stability, and paves the way for faithful cell expansion. He investigates how failure in this pathway impacts the HSC pool and its function, and how it can lead to bone marrow failure or leukemia. Specifically, he aims to determine the molecular mechanisms by which fetal liver HSC expansion is constrained in FA and strategies to alleviate the molecular stress processes that constrain fetal liver HSC expansion in FA.
Dr. Kovuru completed his master's in Biochemistry from Banaras Hindu University and was awarded the Council of Scientific and Industrial Research fellowship to pursue his PhD. He completed his PhD in 2021 from the Department of Biochemistry at the University of Hyderabad, where he studied the role of TLR2 in megakaryocyte development and immune modulation.