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Bo Li, PhD
Bo Li
Core Faculty

Dr. Bo Li is a core faculty member in the Center for Computational and Genomic Medicine.



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Dr. Li investigates the quantitative behaviors of the adaptive immune system using computational, genomics and machine learning approaches. His current research focuses on the following areas:

  • Using the blood T cell receptor repertoire as a novel biomarker to detect early-stage cancer and other immunological conditions
  • How and which cancer cells 'hijack' mitochondria from nearby T cells in vivo
  • Using articifical intelligence-models to identify tumor-associated antibody sequences from large human genomics sequencing data.

Education and Training

PhD, University of Michigan, Ann Arbor MI (Bioinformatics), 2014

BS, Peking University, Peking (Physics), 2009

Titles and Academic Titles

Core Faculty, Center for Computational and Genomics Medicine

Associate Professor, Department of Pathology and Laboratory Medicine

Publication Highlights

Gao GF, Liu D, Zhan X, Li B. Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE. BMC Biol. 2023 Aug; 20(1):191. PMID: 36002830
Feng Q, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep; 13(1):4981. PMID: 36068198
Song L, et al. Comprehensive Characterizations of Immune Receptor Repertoire in Tumors and Cancer Immunotherapy Studies. Cancer Immunol Res. 2022 Jul; 10(7):788-799. PMID: 35605261
Beshnova D, Fang Y, Du M, Sun Y, Du F, Ye J, Chen ZJ, Li B. Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies. Comput Struct Biotechnol J. 2022 Jan; 20:2212-2222. PMID: 35530743

Links of Interest