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Bo Li, PhD
Core Faculty
Dr. Bo Li is a core faculty member in the Center for Computational and Genomic Medicine.
Bio
Dr. Li investigates the quantitative behaviors of the adaptive immune system using computational, genomics and machine learning approaches. His current research focuses on the following areas:
- Using the blood T cell receptor repertoire as a novel biomarker to detect early-stage cancer and other immunological conditions
- How and which cancer cells 'hijack' mitochondria from nearby T cells in vivo
- Using articifical intelligence-models to identify tumor-associated antibody sequences from large human genomics sequencing data.
Education and Training
PhD, University of Michigan, Ann Arbor MI (Bioinformatics), 2014
BS, Peking University, Peking (Physics), 2009
Titles and Academic Titles
Core Faculty, Center for Computational and Genomics Medicine
Associate Professor, Department of Pathology and Laboratory Medicine
Publication Highlights
Gao GF, Liu D, Zhan X, Li B. Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE. BMC Biol. 2023 Aug; 20(1):191. PMID: 36002830
Pan M, Li B. T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies. eLife. 2022 Nov; 11:e81952. PMID: 36350695
Feng Q, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep; 13(1):4981. PMID: 36068198
Song L, et al. Comprehensive Characterizations of Immune Receptor Repertoire in Tumors and Cancer Immunotherapy Studies. Cancer Immunol Res. 2022 Jul; 10(7):788-799. PMID: 35605261
Beshnova D, Fang Y, Du M, Sun Y, Du F, Ye J, Chen ZJ, Li B. Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies. Comput Struct Biotechnol J. 2022 Jan; 20:2212-2222. PMID: 35530743