Dr. Shah's clinical research interests are focused in the areas of Neurofibromatosis Type 1 and Retinoblastoma. These studies range from translational studies to clinical trials of novel therapeutics to international consortiums studying long term effects of therapy. Below are some of the research projects he is pursuing.

Retinoblastoma

• The RIVERBOAT trial studies health outcomes after treatment in patients with retinoblastoma. Gathering health information over time from patients and family members through vision assessments, samples of tissue and saliva, and questionnaires may help doctors learn more about what causes retinoblastoma, identify long-term health outcomes for patients with retinoblastoma, and find out which therapies may be the best for treating retinoblastoma.
• IRiSC: Data on nearly 10,000 patients will be collected and analyzed to understand the following:
  • What is the influence of chemotherapy on the risk of site-specific second primary malignancies?
  • What is the long-term effect of radiation therapy on the risk of second primary malignancies?
  • What is the influence of RB1 mutations on the risk of second primary malignancies?

Neurofibromatosis Type 1

• Clinical Trial of Selumetinib in children with inoperable plexiform neurofibromas
• Influence of puberty on the growth rate of plexiform neurofibromas.

Neuro-oncology

• Arterial Spin Labeling for the diagnosis and prognostication of low grade gliomas
• Carboplatin Rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma.

BS, University of Georgia (Biochemistry and Molecular Biology), 1999

PhD, University of Alabama School of Medicine (Cellular and Molecular Physiology), 2006

MD, University of Alabama School of Medicine, 2008

Pediatrics Internship, Children's Hospital of Philadelphia, 2009

Pediatrics Residency, Children's Hospital of Philadelphia (Integrated Research Program), 2011

Pediatric Hematology Oncology Fellowship, Children's Hospital of Philadelphia, 2014

Pediatric Neuro-oncology Fellowship, Children's Hospital of Philadelphia, 2015

Program Director, Pediatric Neuro-oncology Fellowship

Assistant Professor of Pediatrics

Attending Physician

Children's Oncology Group, 2011-

International Society of Ocular Oncology, 2017-

NF Consortium, 2016-