About The Resuscitation Science Center

By partnering translational and clinical science under one center, the Resuscitation Science Center is uniquely positioned to take a true bench-to-bedside approach to pediatric research.

Clinical Program

An extraordinary strength of our plan is the opportunity to integrate this internationally recognized translational laboratory with successful large clinical resuscitation networks and established avenues for broad dissemination through our leadership roles in national and international scientific committees. To that end, our clinical program’s primary goal is to ensure that promising findings in the translational space are confirmed with high-quality clinical resuscitation investigations and subsequently put into real clinical practice so that all children can benefit. We will focus on several key efforts:

• Conduct high quality clinical resuscitation investigations that will inform national resuscitation guidelines to improve care for children around the world
• Further our quantitative, predictive analytics program targeted at developing a suite of noninvasive physiologic monitoring of resuscitation quality and brain health using machine learning and artificial intelligence algorithms to ensure that all children, not just those with invasive monitoring, can benefit from our scientific discoveries
• Optimize our local pioneering pediatric resuscitation databases, which have been a historical pipeline for important single-center studies and high-impact publications that have driven resuscitation guidelines over the past 20 years
• Develop a scientific node focused on dissemination and implementation research in collaboration with the UPenn Implementation Science Center at the Leonard Davis Institute (PISCE@LDI) to ensure our scientific findings are implemented at the bedside in the most effective and efficient manner to improve patient outcomes
• Develop a long-term outcome clinic in partnership with our neurocritical care infrastructure and collaborators to study and offer supportive and innovative care to patients surviving critical illness.

Translational Program

Our primary goal in the translational program is to create a syndicate that accelerates novel, first-in-human clinical trials of therapeutics, diagnostics, and devices through collaborative scientific platforms. We will continue to collaborate with leading content area experts and coordinate our research interests that span several distinct yet connected domains:

• Develop novel medical countermeasures for chemical and biological threats
• Test efficacy of small molecule therapeutics as well as novel drug development
• Microbubble theranostic discovery
• New biomedical devices design and innovation
• Mitochondrial genomics
• Discover biomarkers used to create neurodiagnostic assays
• Design and utilize computational biology models.