Metabolism | CHOP Research Institute


Published on
Mar 18, 2024
Learn how the NAD metabolite controls how well T and B cells can detect their antigens, leading to quicker immune responses.

Promoting and fostering new research ventures and collaborations among our community of basic and translational investigators, clinician-scientists, and clinicians with shared interests in skeletal health and diseases

The purpose of this study is to find out if JR-141, an experimental drug, works better than the standard treatment, idursulfase, for MPS II (Hunter Syndrome) and how safe and effective it is in the management of central nervous system symptoms and other body symptoms related to MPS II.

Establish connections between biomarkers and the stage and grade of bone and cartilage disease in MPS patients.

The Kelly Lab is focused on deciphering the metabolic origins of disease toward novel therapeutic targets aimed at heart failure.

Dr. Kelly’s research career began with deciphering the genetic basis of inborn errors in metabolism in children, followed by a series of breakthrough discoveries relevant to the diagnosis and treatment of common forms of heart failure in the general population.

dankelly [at]

The Mitchell Lab uses epidemiological methods to investigate determinants of energetic behavior.

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

bailisw [at]
Published on
Jun 16, 2021
Meet our featured Faculty Spotlight scientist for June, Will Bailis, PhD.

The purpose of this research study is to test and adapt new techniques for performing magnetic resonance imaging (MRI). MRI provides pictures of the inside of the body and information about chemicals the body makes.