Septic Shock

The study will use residual blood collected from clinical samples collected around the time of meeting study inclusion to identify subphenotypes of subjects with shared underlying protein biomarker profiles, correlate subphenotypes with PICU morality, and assess degree of overlap between subphenotypes and classical syndromic definitions.

This study measures plasma biomarkers in children enrolled in PRoMPT BOLUS with existing stored samples which were collected at randomization in order to assess the for differential effects of fluid assignment on MAKE30 across risk strata using two distinct biomarker-based mortality prediction models (Aim 1) and separately across two different b

The LUng iNjury Group at Children's Hospital of Philadelphia is dedicated to advancing the care of children who have difficulty breathing, with a focus on hospitalized children with severe respiratory failure requiring mechanical ventilation.

The Pediatric Sepsis Program will lead the international medical and scientific communities to determine what causes sepsis, the best methods for early detection and resuscitation, therapies to successfully reverse the effects of sepsis, and appropriate long-term follow-up for infants, children, and adolescents.