Pediatric Leukemia | CHOP Research Institute
 

Pediatric Leukemia

This study enrolls patients that have been diagnosed with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or mixed phenotype acute leukemia (MPAL) that has either come back (‘relapsed’) or does not respond to therapy (‘refractory’).

This study enrolls patients that have been diagnosed with acute leukemia associated with a KMT2A (MLL) gene rearrangement (referred to as KMT2Arearranged, or KMT2A-R).

This study involves taking a study drug called venetoclax with or without standard of care chemotherapy.

The overall goals of this study are to find the best dose of bosutinib that we can give safely, and to find out what effects, good and/or bad, bosutinib has on children and adolescents with Chronic Myeloid Leukemia (CML).

The Tan Laboratory studies the fundamental question of transcriptional regulation during normal development and disease. It involves a complex interplay of multiple transcription factors and epigenetic factors in the context of a three-dimensional chromosomal environment.

Dr. Tan uses experimental and computational approaches to study normal development and cancer. His laboratory is using the integrative approach to dissect the gene regulatory networks controlling embryonic hematopoiesis, T cell differentiation, and oncogenesis. He is also developing computational algorithms for constructing models of transcriptional regulatory and signaling networks by integrating multi-dimensional genomic, epigenomic, and transcriptomic datasets.

E-mail:
tank1 [at] chop.edu
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Dec 30, 2016
The end of the year has come up fast, and so have important advances in pediatric research at Children's Hospital of Philadelphia. This week's In the News starts off with a celebration of two remarkable patients and their dedicated pediatric oncologist.