The mission of the Clinical Pharmacology RAG is to support CHOP investigators engaged in clinical pharmacology research, foster collaborations within the CHOP/Penn research community, and create additional educational opportunities for trainees.
The Center for Precision Medicine for High-risk Pediatric Cancer Frontier Program builds upon ongoing precision medicine efforts across CHOP departments to define and expand treatment options.
The John Lab studies metabolism in the setting of pediatric infections, in order to identify new anti-infective drug targets, understand drug resistance, and develop ways to diagnose disease.
The Maris Lab investigates the molecular and genetic mechanisms contributing to the development and progression of neuroblastoma, a common childhood cancer.
The Cancer Pharmacology Laboratory supports clinical trials of new mechanistically targeted and immune-based anticancer drugs by conducting pre-clinical and clinical pharmacology studies of the agents. The lab also studies conventional anticancer drugs to develop more rational and effective dosing methods, and the lab team is developing ci
Research in the Abdulmalik Laboratory focuses on the development of novel therapies for the hemoglobinopathies, with a particular emphasis on developing and validating novel therapeutic agents for sickle cell disease.
The Wilson Lab studies the inherited neuro- and cardio-degenerative mitochondrial disorder, Friedreich ataxia (FA). The lab also constructed the first random shRNA-expressing libraries and is using these libraries for drug discovery in a variety of disorders.
