Hematopoiesis | CHOP Research Institute


The Thom Lab, an integrated genomics and cell biology lab, aims to define novel factors that regulate blood cell development and function in order to augment in vitro blood cell production.

Published on
Dec 20, 2022
Our December Faculty Spotlight scientist, Christopher Thom, MD, PhD, works at the intersection of genetics, blood biology, and cellular therapeutics.

Dr. Thom uses computational and cellular approaches to understand genetic determinants of hematopoiesis. Dr. Thom aims to harness related insights to improve in vitro blood cell production from induced pluripotent stem cells.

thomc [at] chop.edu

The Gadue Lab studies human pancreatic and hematopoietic development and associated diseases using human pluripotent stem cells. The lab’s research efforts are devoted to directed differentiation and CRISPR-based genome engineering of stem cells to use in the study and development of treatments for diabetes and blood disorders.

The Comprehensive Bone Marrow Failure Center brings together physicians and researchers to provide state-of-the-art diagnostics, clinical care, and investigational studies, as well as basic research focused on acquired and inherited bone marrow failure.

The Blobel Lab investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin, gearing its basic science discoveries toward genetic and epigenetic treatment modalities.