Inflammatory Bowel Disease | CHOP Research Institute

Inflammatory Bowel Disease

Published on
Aug 14, 2023
By studying lab-grown organoids derived from patients’ stem cells, the Hamilton Lab seeks to better understand and treat IBD.

Evaluate the impact of non-persistent and persistent chemical exposures on autoimmunity, gene expression and the microbiome in children with and without Crohn’s disease.

Published on
Sep 21, 2022
A high school student in the lab of Dr. Kathryn Hamilton won two science fair awards for research he conducted at CHOP.

Dr. Mattei is an attending physician in the Division of General, Thoracic and Fetal Surgery and specializes in pediatric surgical oncology, inflammatory bowel disease, and minimally invasive and robotic surgery. His research interests are in oncology and IBD.

mattei [at]

The Penn Human Intervention Core offers a wide array of services to assist with the design and implementation of microbiome studies.

The Penn Microbial Culture and Metabolomics Core features facilities and equipment for the aerobic and anaerobic culture of microbial species in both batch and continuous systems, as well targeted metabolomics services.

The Penn High-throughput Screening (PHTS) Core provides the PennCHOP research community with professional PHTS screening services to identify genes or organic small molecule modulators of signaling pathways, cellular phenotypes, and protein function in models of human disease.

The goals of the Penn Acute Care Biobanking Core are to encourage and facilitate microbiome-focused research in the pathogenesis, diagnosis, and treatment of patients with critical illness.

The University of Pennsylvania launched the Penn Gnotobiotic Mouse Facility (PGMF) to aid new research in this area and provide investigators with germ-free animal models to further their research.

The Center supports the planning of microbiome projects, DNA purification, library preparation, high-throughput sequencing, and bioinformatic analysis of the output.