Epigenetics | CHOP Research Institute


Dr. Wolpaw’s laboratory seeks to develop an understanding of how tumor heterogeneity and epigenetics impact inflammatory signaling and immunotherapy responses in pediatric solid tumors with a goal of developing more efficacious, less toxic therapies to treat these devastating diseases.

Published on
Jul 18, 2022
CHOP researchers develop tool that accelerates DNA methylation characterization.

The Center for Spatial and Functional Genomics is focused on uncovering the correct functional context of variants identified by genome-wide association studies in order to translate these discoveries into meaningful benefits for pediatric care.

Uncovering the correct functional context of genetic variants to translate genome-wide association studies into meaningful benefits for pediatric care.

Published on
Jan 13, 2022
Peter Choi, PhD, received the prestigious award for research into the hidden determinants of RNA splicing.
Published on
Dec 20, 2021
Dr. Carpenter’s research seeks to better understand how environmental factors affect the origins of disease via epigenetic modifications.
Published on
Aug 31, 2021
Our August Faculty Spotlight scientist, Naiara Akizu Lopez, PhD, studies the genetic and epigenetic mechanisms of neurologic disorders in children.
Published on
Aug 19, 2021
Colin Conine, PhD, a 2021 Pew Scholar, studies small RNAs in sperm to understand how they influence traits of the offspring they produce.

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

bailisw [at] chop.edu

The Wells Laboratory studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.