Very Early Onset Inflammatory Bowel Disease | CHOP Research Institute

Very Early Onset Inflammatory Bowel Disease

Published on
Sep 23, 2022
September's featured Faculty Spotlight scientist is Kathleen Sullivan, MD, PhD.

The Sullivan Lab has a broad interest in immune dysfunction. This can underlie susceptibility to infections and autoimmunity and inflammation. The investigators in the lab use cutting-edge approaches to investigate cause in individual patients and to look at population-wide causes of disease.

The Hamilton Lab studies epithelial cells in the intestine and colon and the roles they play in maintaining human health.

Generating new insights from multidisciplinary translational research to provide personalized therapy worldwide for more children with inflammatory bowel disease.

Published on
Apr 3, 2019
Marcella Devoto, PhD; Judith Kelsen, MD; and colleagues are using technologies like whole exome sequencing to uncover the genetic basis of very early onset inflammatory bowel disease.

Dr. Kelsen’s research focus is on the genetic, immunologic, and microbiomic causes of very early onset inflammatory bowel disease. Through a multidisciplinary team approach, Dr. Kelsen and her colleagues perform genetic sequencing to identify causative genetic variants in children with VEO-IBD, study the function of these variants, and use this information to improve the clinical outcomes for these children.

kelsen [at]
Published on
Jan 16, 2019
Clinician-scientists at CHOP and Penn leverage their collective brainpower to narrow down the toughest of these tough diagnoses.

Dr. Sullivan's research focuses on new and rare immunodeficiencies. She has a long-standing interest in one of the most common of the primary immunodeficiencies – chromosome 22q11.2 deletion syndrome. She also investigates common variable immunodeficiency, as well as the genetics and epigenetics of systemic lupus erythematosus.

sullivank [at]
Published on
Jul 18, 2018
Symposium focuses on translational research and clinical discussions on the forefront of pediatric inflammatory bowel disease and very early onset IBD.
Published on
Jun 1, 2018
From antibiotic stewardship in the NICU to reducing child mortality rates, here's your bi-weekly update on CHOP research news.