Cardiovascular Diseases | CHOP Research Institute

Cardiovascular Diseases

We are currently enrolling adolescents ages 15-21 of South Asian ancestry, African American ancestry, and European American or "White" ancestry.

The laboratory led by Michael Chorny, PhD, designs delivery systems for drugs and biotherapeutics, focusing on vascular proliferative diseases and high-risk malignancies. Biodegradable nanoparticles and prodrugs are optimized to enhance and extend therapeutic activity, and minimize adverse effects.

Providing an innovative program focused on the molecular genetic basis of disease.

Published on
Nov 19, 2019
Using eMERGE Network data, researchers identified genome-wide significant loci that might be biomarkers for risk of cardiovascular disease.

Dr. Mayne is an epidemiologist whose research focuses on preventing cardiovascular disease and promoting healthy behaviors in children and their families. She employs multilevel and longitudinal methods to study how factors at the individual, family, neighborhood, and policy level influence risk factor behaviors and cardiometabolic outcomes. She is also engaged in research to promote innovation in pediatric primary care.

maynes [at]
Published on
Dec 14, 2018
In this week’s research roundup: personalized gene therapies reach key milestones and scientists probe CAR T-cell resistance.

Dr. Rossano's extensive research experience primarily involves the epidemiology and outcomes of cardiovascular disease in children, and multi-institutional collaborative observational and interventional studies. His particular research interests include evaluating the treatment and outcomes of pediatric cardiomyopathy, heart failure, and transplantation.

rossanoj [at]
Published on
Dec 2, 2016
Welcome back to our regular roundup of research news from Children's Hospital of Philadelphia! Now that we are bringing you these updates biweekly, we have an even richer collection of stories to share. This week's highlights include an important update for clinicians to recognize that hypertension risk may be underdiagnosed in children; research on the ongoing needs of childhood cancer
Published on
Apr 17, 2014
Two recent studies expand the list of genes associated with body fat and body mass index (BMI), and their connection to heart disease, high blood pressure, and diabetes.