Small Molecule and Metabolite Core



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Advance the quality and scope of your research with easy access to state-of-the-art quantitative analysis with the Small Molecule and Metabolite Core.

Our helpful and friendly staff provides expertise for you to take advantage of the latest technological advances in quantitative analysis, including liquid chromatography-tandem mass spectrometry, gas chromatography mass spectrometry, and ion ratio mass spectrometry systems. Our team excels at a variety of small molecule quantitative bioanalytical applications:

  • Assay development, validation, and implementation for the concentration analysis of drugs, metabolites and biomarkers in:
    • blood, serum, plasma, urine, ultrafiltrate, and micro-dialysate
    • whole blood volumetric absorptive microsampling allowing for microsampling from a finger stick of blood
  • Fast assay development and analysis of drugs, metabolites, and biomarkers in blood, plasma, serum, and tissue homogenates of preclinical samples
  • Plasma protein binding
  • Formulation stability
  • Study start up

The Core staff are happy to consult with you to plan, design, and develop unique approaches to your research project in academic, biotechnological, pharmaceutical, and clinical medicine. All investigators within and outside the Children’s Hospital of Philadelphia and University of Pennsylvania campus are welcome to get started.