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Scientific Review of Protocols

Published on · Last Updated 2 years 10 months ago


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Departments/Divisions within CHOP have established a number of scientific protocol review committees whose goals are to i.) support CHOP’s meeting the Association for the Accreditation of Human Research Protection Programs (AAHRPP) requirements ii.) improve upon the scientific quality of human subjects research conducted at CHOP and iii.) decrease the burden on our IRB committees that must take into account the scientific basis for the proposed research when evaluating the risks and benefits associated with the proposal.

Established committees include:

  • Existing CHOP or UPenn Scientific Review Committees (e.g., Cancer Center, IND/IDE Scientific Review Committee)
  • Existing Divisional or Departmental Scientific Review Committees
  • Scientific review committees constituted by or between Departments, Divisions, or Centers of Emphasis

The following types of protocols are exempt from scientific review (unless requested by the IRB):

  • Protocol/grants peer-reviewed by a Federal-funding agency (e.g., NIH, CDC, DOD)
  • Protocol/grants peer-reviewed by a national foundation (e.g., American Heart Association)
  • Protocol/grants conducted by an industry sponsor
  • Research that does not require direct involvement of human subjects (e.g., chart review or research exempt from IRB review)
  • Studies exempt from IRB oversight

Effective June 1, 2008, all other protocols must undergo internal scientific review by an established scientific committee prior to IRB submission. For investigator held INDs or IDEs, the IND/IDE Scientific Review Committee will complete the scientific review.

For more information and to view instructions for submitting a study for scientific review, establishing a new scientific review committee, scientific review committee structure, and viewing scientific review committee forms, please visit the @CHOP Scientific Review Committees Page.