The Wallace Laboratory investigates the role of mitochondria in human evolution, health, and disease. It is one of the main labs in CHOP’s Center for Mitochondrial & Epigenomic Medicine, which aims to unite biomedical scientists, clinicians, and patients, and their families to determine the causes and generate the cures for metabolic and degenerative diseases, cancer, and aging.
Researchers at The Children’s Hospital of Philadelphia were on the road this week. Our weekly In The News update first takes us to sunny Orlando, Fla., where the 19th Annual Update on Pediatric and Congenital Cardiovascular Disease began Feb. 24.
For more than two decades, mutations in a gene located in the DNA of mitochondria have been classified as a mitochondrial disease and linked to a particular set of symptoms. However, according to new findings from researchers at Children's Hospital of Philadelphia (CHOP), mutations in this gene, which encodes an essential part of the mitochondrial motor known as ATP synthase that generates cellular energy, are much more variable than previously thought.