The cure rate for children with neuroblastoma is unacceptable, making it imperative that new therapies are developed. Dr. Bosse's laboratory is focused on discovering and developing new neuroblastoma cell surface immunotherapeutic targets. Along with his colleagues, Dr. Bosse's aim is to capitalize on the robust differential expression of these molecules with immune-based therapies and also define their mechanisms of overexpression and roles in tumorigenesis.
Dr. Song works to elucidate the cellular and molecular basis governing the formation, maintenance, and function of neural circuits under physiological and pathological conditions, using both Drosophila and mammalian models.
Dr. Bauer's academic and clinical career are focused on improving the care of children and adolescents with thyroid disease. He has extensive experience and knowledge of thyroid pathophysiology and tumorigenesis, and has been critical to the clinical success of the Children's Hospital of Philadelphia Thyroid Center.
Dr. Diskin's research is focused on translational genomics in childhood cancers. Her laboratory seeks to identify the genetic basis of childhood cancers by combining quantitative computational methods with rigorous "wet-lab" experimental approaches. In parallel, she has developed, and is applying, a proteogenomic approach to identify novel immunotherapeutic targets for high-risk and relapsed pediatric malignancies.
Dr. Choi's research focuses on the role of RNA-binding proteins in the regulation of alternative splicing and how mutations in these factors contribute to cancer. He uses a combination of genetically-engineered models and high-throughput approaches to better understand how alternative splicing influences cellular function and to identify potential opportunities for therapeutic intervention.
The long-term goal of the Song Lab is to elucidate the cellular and molecular basis governing the formation, maintenance, and function of neural circuits under physiological and pathological conditions, using both Drosophila and mammalian models
As a multidisciplinary center of excellence, providing specialized care for children with thyroid disorders and participating in collaborative clinical and translational basic science research within the University of Pennsylvania healthcare system and with other pediatric thyroid centers across North America.
Translational genomics in childhood cancers is the central focus of the Diskin Lab, which works to identify the inherited and acquired genetic drivers of cancer by combining quantitative computational methods with rigorous experimental approaches in the lab. In parallel, the team has developed and applied a proteogenomic approach to identify novel immunotherapeutic targets for high-risk and relapsed pediatric malignancies.
Research in the Cole Lab focuses on identifying therapeutic vulnerabilities within molecularly defined subsets of pediatric central nervous system malignancies. The long-term goal of the lab is to identify effective therapies and improve the cure rate of children with malignant brain tumors.