Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.
Dr. Thomas-Tikhonenko has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression. Within that research space, his studies focus mainly (but not exclusively) on RNA-based regulatory mechanisms, such as microRNAs and alternative mRNA splicing.
In the lab of Paula Oliver, PhD, associate professor of Pathology at Children’s Hospital of Philadelphia, a group of researchers led by Awo Layman, PhD; Guoping Deng, PhD; and Claire O’Leary, PhD, studied the influential events that transpire when, as Dr. Layman described it to us, a type of immune cell called a regulatory T cell suffers a “loss of identity.”
The Tan Laboratory studies the fundamental question of transcriptional regulation during normal development and disease. It involves a complex interplay of multiple transcription factors and epigenetic factors in the context of a three-dimensional chromosomal environment. Using experimental genomics and computational modeling, the lab has been studying transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.
Understanding the mechanisms by which the skeleton forms and grows in healthy babies and children and using this information to uncover the pathogenesis of rare and common musculoskeletal disorders by working with animal models of the diseases.