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Results for Transcription Factors

1 - 10 of 51

Véronique Lefebvre, PhD
Véronique Lefebvre

Dr. Lefebvre investigates the genetic mechanisms that generate the diversity of cell types composing the body. Her emphasis is on deciphering how proteins called SOX transcription factors specify stem cells and highly specialized cells in the skeleton, how changes in these factors cause skeletal diseases, and how these factors also control other processes, including brain development and intellectual disability diseases.

E-mail:
lefebvrev1 [at] chop.edu
Gerd Blobel, MD, PhD
Gerd Blobel

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.

E-mail:
blobel [at] chop.edu
Andrew D. Wells, PhD
Andrew D. Wells

Dr. Wells studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.

E-mail:
wellsa [at] chop.edu
Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu
Christopher J. Cardinale, MD, PhD
Christopher J. Cardinale

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:
cardinalec [at] chop.edu
Daniel P. Kelly, MD
Daniel P. Kelly

Dr. Kelly’s research career began with deciphering the genetic basis of inborn errors in metabolism in children, followed by a series of breakthrough discoveries relevant to the diagnosis and treatment of common forms of heart failure in the general population.

E-mail:
dankelly [at] pennmedicine.upenn.edu
Natalie A. Terry, MD, PhD
Natalie A. Terry, MD, PhD

Dr. Terry's research focuses on the mechanisms of malabsorption in congenital diarrheal disorders and short bowel syndrome.

E-mail:
terryn [at] chop.edu
Thomas De Raedt, PhD
Thomas De Raedt

Dr. De Raedt researches pediatric high grade glioma development and aims to understand the involvement of crucial pathways. He investigates pathway interaction, and explores ways to develop therapies through analyzing human tumors, performing cellular studies, and developing accurate mouse models. This allows Dr. De Raedt and his team to perform novel pre-clinical studies that can lead to clinical trials.

E-mail:
deraedtt [at] chop.edu
Ana G. Cristancho, MD, PhD
Ana G. Cristancho

Dr. Cristancho is a child neurologist specializing in Fetal and Neonatal Neurology. Her research focuses on understanding the mechanisms that regulate the extent of disabilities some kids have after prenatal and neonatal brain injury. Her goal is to help develop novel therapeutic interventions.

E-mail:
cristanchoa [at] chop.edu
Diva D. De León-Crutchlow, MD, MSCE
Diva D. De León-Crutchlow

Dr. De Leon-Crutchlow’s translational research program focuses on examining the pathophysiology of disorders of insulin regulation, identifying novel therapeutic targets, and developing new therapies for these conditions. The program approach includes patient-oriented research and bench research employing mouse models and primary islet cultures.

E-mail:
deleon [at] chop.edu
1 - 10 of 51

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In this section

Filter By

  • Principal Investigator / Faculty (11)

Organizations

  • Department of Pathology and Laboratory Medicine (6)
  • Center for Childhood Cancer Research (5)
  • Division of Hematology (4)
  • Department of Pediatrics (3)
  • PolicyLab (3)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (3)
  • Center for Applied Genomics (2)
  • Center for Autism Research (2)
  • Center for Mitochondrial and Epigenomic Medicine (2)
  • Center for Pediatric Clinical Effectiveness (2)
  • Division of Human Genetics (2)
  • Division of Oncology (2)
  • Mir Laboratory (2)
  • Office of Academic Training and Outreach Programs (2)
  • Biomedical Optical Devices to Monitor Cerebral Health (1)
  • Center for Computational and Genomic Medicine (1)
  • Center for Data-Driven Discovery in Biomedicine (1)
  • Center for Injury Research and Prevention (1)
  • Choi Laboratory (1)
  • Department of Biomedical and Health Informatics (1)
  • Department of Surgery (1)
  • Division of Allergy and Immunology (1)
  • Division of Cancer Pathobiology (1)
  • Division of Cardiology (1)
  • Division of Emergency Medicine (1)
  • Division of Infectious Diseases (1)
  • Division of Neonatology (1)
  • Division of Nephrology (1)
  • Division of Neurosurgery (1)
  • Division of Orthopaedic Surgery (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Pediatric Center of Excellence in Nephrology (1)
  • Roberts Individualized Medical Genetics Center (1)
  • Romberg Laboratory (1)
  • Spatial and Functional Genomics Collaborative (1)
  • Spatial and Functional Genomics Research Affinity Group (1)
  • Stress Neurobiology Program (1)
  • Weitzman Laboratory (1)
  • Wolfson Family Laboratory for Clinical and Biomedical Optics (1)
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