Dr. Behrens' research focuses on the pathogenesis and treatment of cytokine storm syndromes, including the hemophagocytic syndromes Hemophagocytic Lymphohistiocytosis (HLH) and Macrophage Activation Syndrome (MAS).
Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.
Four junior investigators from the Children's Hospital of Philadelphia's Department of Pediatrics have been chosen to receive the prestigious 2013 Young Physician-Scientist Award by the American Society for Clinical Investigation (ASCI).
The Behrens Lab is interested in the pathogenesis and treatment of cytokine storm syndromes, including the hemophagocytic syndromes Hemophagocytic Lymphohistiocytosis (HLH) and Macrophage Activation Syndrome (MAS). These are uniquely pediatric immunologic conditions that result in severe systemic inflammation and death if unrecognized and untreated.
The Marks Lab aims to dissect the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles and the assembly, delivery, and function of their contents, and to understand how these processes are impacted by genetic diseases. The lab focuses on processes of importance to the pigmentary, immune, and hemostasis systems, with broad application to understanding organelle biogenesis, signaling, and function within the endolysosomal system.