Dr. Thomas-Tikhonenko has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression. Within that research space, his studies focus mainly (but not exclusively) on RNA-based regulatory mechanisms, such as microRNAs and alternative mRNA splicing.
The cure rate for children with neuroblastoma is unacceptable, making it imperative that new therapies are developed. Dr. Bosse's laboratory is focused on discovering and developing new neuroblastoma cell surface immunotherapeutic targets. Along with his colleagues, Dr. Bosse's aim is to capitalize on the robust differential expression of these molecules with immune-based therapies and also define their mechanisms of overexpression and roles in tumorigenesis.
A leading physician-researcher at Children’s Hospital of Philadelphia (CHOP) has received an award from the QED Program of the University City Science Center to help develop an innovative T-cell based treatment for the childhood cancer neuroblastoma.
Physician-scientists from Children’s Hospital of Philadelphia (CHOP) contributed crucial data and expertise to the first pan-cancer analysis of children’s cancer, published today in the journal Nature. Pan-cancer analyses identify similarities and differences among the biological changes across diverse types of cancer, with the aim of discovering insights for improved care.