Dr. McCormack investigates the intersection of neuroendocrinology and metabolism. Her translational research program involves two areas. The first involves studying those with genetic disorders, including primary mitochondrial diseases and Friedreich's ataxia, with characterized risk for diabetes mellitus. Second, Dr. McCormack focuses on brain disorders associated with excess weight gain, including brain tumor-related hypothalamic obesity syndrome and idiopathic intracranial hypertension.
Dr. Koyama's research focuses on Hereditary Multiple Exostoses (HME), a genetic disorder that causes the development of multiple benign tumors on the surface of the metaphyses of long bones. Based on his extensive knowledge of the normal processes of skeletal development and growth, Dr. Koyama's research aims to clarify the molecular mechanisms of HME formation and growth.
Dr. Pacifici's biomedical research spans three decades and has explored mechanisms of skeletal development and growth in fetal and postnatal life. Specifically, his focus has been on identifying the cellular and molecular mechanisms that regulate the differentiation of progenitor cells and permit assembly of distinct skeletal structures, and on aberrations of these mechanisms in pediatric skeletal disorders.
Dr. Mostoufi-Moab's clinical and research program is focused on endocrine late effects after childhood cancer therapy. She has unique dual training in pediatric endocrinology and oncology with a master's degree in clinical epidemiology. The goal of her research program is to pursue a mechanistic understanding of metabolic and endocrine disorders that occur due to cancer therapy.
The Lefebvre Lab advances the understanding of skeletal and neurodevelopmental syndromes. To this end, the team is decrypting mechanisms controlling the identity and activities of stem cells and differentiated cells governing these processes. A main focus is on SOX transcription factors, proteins with master roles in driving cell type-specific genetic programs, and alterations that cause skeletal, neurodevelopmental, and other diseases.
The overall goal of the Pei Lab of Cardiac Endocrinology is to understand how different organs react to energy cues and communicate with each other to maintain whole-organism homeostasis in both physiological and pathological contexts.
Understanding the mechanisms by which the skeleton forms and grows in healthy babies and children and using this information to uncover the pathogenesis of rare and common musculoskeletal disorders by working with animal models of the diseases.
Biomedical research in the Pacifici Laboratory spans three decades and has explored mechanisms of skeletal development and growth in fetal and postnatal life. Specifically, the lab’s focus has been on identifying the cellular and molecular mechanisms that regulate the differentiation of progenitor cells and permit assembly of distinct skeletal structures, and on aberrations of these mechanisms in pediatric skeletal disorders.