Dr. Weiss' research focuses on epidemiology of pediatric sepsis and mitochondrial dysfunction in sepsis-associated organ injury. The driving hypothesis for his research is that alterations in mitochondrial bioenergetics contribute to organ injury and immune dysregulation in a subset of children with sepsis.
Dr. Coffin’s research interests focus on the epidemiology and prevention of healthcare-associated infections in the pediatric population. She also investigates the epidemiology of pediatric respiratory viral infections, with a particular emphasis on influenza.
Dr. Puopolo helped lead the research team that developed and validated multivariate prediction models for neonatal early-onset sepsis risk assessment. Her current research addresses the impacts of maternal immunity, perinatal antibiotic exposure, and neonatal infection on infant and childhood health.
The research interests of Dr. Downes focus on antimicrobial clinical pharmacology and pharmacoepidemiology in children with a goal to identify novel approaches to optimize efficacy, minimize toxicity, and limit antimicrobial resistance from antibiotics.