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Results for RNA Genomics

1 - 10 of 61

Yi Xing, PhD
Yi Xing

Dr. Xing is the Executive Director of the Department of Biomedical and Health Informatics, the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at CHOP, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. His research focuses on computational biology and genomics of RNA processing and regulation.

E-mail:
xingyi [at] chop.edu
Sharon J. Diskin, PhD
Sharon J. Diskin

Dr. Diskin's research is focused on translational genomics in childhood cancers. Her laboratory seeks to identify the genetic basis of childhood cancers by combining quantitative computational methods with rigorous "wet-lab" experimental approaches. In parallel, she has developed, and is applying, a proteogenomic approach to identify novel immunotherapeutic targets for high-risk and relapsed pediatric malignancies.

E-mail:
diskin [at] chop.edu
Amanda M. Ackermann, MD, PhD
Amanda M. Ackermann

Dr. Ackermann studies diabetes (types 1 and 2) and congenital hyperinsulinism using mouse models, cell lines, and primary human tissue. She aims to identify novel pathways regulating beta cell insulin secretion, leading to innovative therapeutic strategies for these disorders. Current studies include in vivo mouse physiology, ex vivo human islet physiology, CRISPR-Cas9 gene editing, epigenetic modification, and single-cell functional genomics.

E-mail:
ackermanna [at] chop.edu
Colin Conine, PhD
Colin C. Conine

Dr. Conine works to understand the functions of small RNAs in reproduction, epigenetic inheritance, and development. His research focuses on how small RNAs in sperm transmit epigenetic information to offspring, as well as their involvement in male fertility.

E-mail:
conine [at] chop.edu
Peter S. Choi, PhD
Peter S. Choi Headshot

Dr. Choi's research focuses on the role of RNA-binding proteins in the regulation of alternative splicing and how mutations in these factors contribute to cancer. He uses a combination of genetically-engineered models and high-throughput approaches to better understand how alternative splicing influences cellular function and to identify potential opportunities for therapeutic intervention.

E-mail:
choip [at] chop.edu
Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu

In The News: ADHD Symptoms, Skull Formation, Vision Disorders After Concussion

Published on
Jul 22, 2022
in Cornerstone Blog
Our Scientists’ Research Highlighted In the News
Learn about novel findings from our Children’s Hospital of Philadelphia researchers.

What Viruses Can Tell Us About RNA Processing: Q&A with the Weitzman Lab

Published on
Jul 14, 2022
in Cornerstone Blog
Recent research from the Weitzman Lab sheds light on how a virus manipulates and takes control of RNA processing pathways.
Weitzman Lab scientists share their discoveries about how viruses can manipulate RNA processing.

Services at CHOP Single Cell Technology Core

Published on
Jul 11, 2022
in Announcements
Services at CHOP Single Cell Technology Core
The Single Cell Technology Core provides access to cutting-edge single cell, spatial, and in situ technologies to our research community.

Arcus Enables COVID-19 Variant Research: Q&A with Scott Haag, PhD

Published on
Jun 15, 2022
in Cornerstone Blog
Arcus Enables COVID-19 Variant Research
Learn how computational science experts help advance our data-driven research at CHOP.
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In this section

Filter By

  • Principal Investigator / Faculty (6)

Organizations

  • Center for Computational and Genomic Medicine (10)
  • Center for Applied Genomics (5)
  • Department of Pathology and Laboratory Medicine (5)
  • Center for Data-Driven Discovery in Biomedicine (4)
  • Department of Biomedical and Health Informatics (4)
  • Department of Pediatrics (4)
  • Department of Surgery (3)
  • Division of Allergy and Immunology (3)
  • PolicyLab (3)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (3)
  • Center for Applied Genomics Laboratory (2)
  • Center for Childhood Cancer Research (2)
  • Center for Injury Research and Prevention (2)
  • Center for Mitochondrial and Epigenomic Medicine (2)
  • Center for Single Cell Biology (2)
  • Division of Emergency Medicine (2)
  • Division of Neonatology (2)
  • Division of Neurology (2)
  • Division of Neurosurgery (2)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (2)
  • Grant Laboratory (2)
  • Single Cell Technology Core (2)
  • Spatial and Functional Genomics Collaborative (2)
  • Spatial and Functional Genomics Research Affinity Group (2)
  • Wells Laboratory (2)
  • Akizu Laboratory (1)
  • Bailis Laboratory (1)
  • Blobel Laboratory (1)
  • Cancer Immunotherapy (CAR-T) (1)
  • Center for Autism Research (1)
  • Choi Laboratory (1)
  • Comprehensive Bone Marrow Failure Center (1)
  • Division of Cancer Pathobiology (1)
  • Division of Cardiology (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Human Genetics (1)
  • Division of Infectious Diseases (1)
  • Division of Orthopaedic Surgery (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • eMERGE (1)
  • High Throughput Sequencing Core (1)
  • Lefebvre Laboratory (1)
  • Leukodystrophy Center of Excellence (1)
  • Lin Laboratory (1)
  • Minds Matter Concussion Program (1)
  • Roberts Individualized Medical Genetics Center (1)
  • Romberg Laboratory (1)
  • Thomas-Tikhonenko Laboratory (1)
  • Thyroid Center (1)
  • Translational Research Program in Pediatric Orthopaedics (1)
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