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Results for RNA Genomics

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Yi Xing, PhD
Yi Xing

Dr. Xing is the Executive Director of the Department of Biomedical and Health Informatics, the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at CHOP, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. His research focuses on computational biology and genomics of RNA processing and regulation.

E-mail:
xingyi [at] chop.edu
Sharon J. Diskin, PhD
Sharon J. Diskin

Dr. Diskin's research is focused on translational genomics in childhood cancers. Her laboratory seeks to identify the genetic basis of childhood cancers by combining quantitative computational methods with rigorous "wet-lab" experimental approaches. In parallel, she has developed, and is applying, a proteogenomic approach to identify novel immunotherapeutic targets for high-risk and relapsed pediatric malignancies.

E-mail:
diskin [at] chop.edu
Amanda M. Ackermann, MD, PhD
Amanda M. Ackermann

Dr. Ackermann studies diabetes (types 1 and 2) and congenital hyperinsulinism using mouse models, cell lines, and primary human tissue. She aims to identify novel pathways regulating beta cell insulin secretion, leading to innovative therapeutic strategies for these disorders. Current studies include in vivo mouse physiology, ex vivo human islet physiology, CRISPR-Cas9 gene editing, epigenetic modification, and single-cell functional genomics.

E-mail:
ackermanna [at] chop.edu
Colin Conine, PhD
Colin C. Conine

Dr. Conine works to understand the functions of small RNAs in reproduction, epigenetic inheritance, and development. His research focuses on how small RNAs in sperm transmit epigenetic information to offspring, as well as their involvement in male fertility.

E-mail:
conine [at] chop.edu
Peter S. Choi, PhD
Peter S. Choi Headshot

Dr. Choi's research focuses on the role of RNA-binding proteins in the regulation of alternative splicing and how mutations in these factors contribute to cancer. He uses a combination of genetically-engineered models and high-throughput approaches to better understand how alternative splicing influences cellular function and to identify potential opportunities for therapeutic intervention.

E-mail:
choip [at] chop.edu
Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu

Snapshot Science: Can a New Computational Tool Discover and Quantify RNA Molecules More Accurately?

Published on
Mar 23, 2023
in Cornerstone Blog
Snapshot Science: Can a New Tool Read RNA Molecules More Accurately?
Researchers in the Center for Computational and Genomic Medicine developed a new tool to read RNA more accurately.

In the News: ASCI Membership, STAT Madness, Brain Chart, Single Ventricle Research Fund

Published on
Mar 3, 2023
in Cornerstone Blog
In the News: ASCI Membership, STAT Madness, Brain Chart
In this news roundup, learn about the achievements of CHOP researchers from societal inductions to grant- and grand-prize recipients.

In the News: Foundational Gift, Gates Grant, Community-engaged Research

Published on
Feb 17, 2023
in Cornerstone Blog
In the News: Foundational Gift, Community Partnerships
In this news roundup, learn how CHOP researchers are advancing research for neurological diseases and engaging in community collaborative research.

First Arcus Omics Data Launch: Q&A With Ingo Helbig, MD

Published on
Feb 15, 2023
in Cornerstone Blog
First Arcus Omics Data Launch: Q&A With Ingo Helbig, MD
Ingo Helbig, MD, discusses the Arcus Omics Data launch at CHOP in a Q&A.
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In this section

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  • Center for Computational and Genomic Medicine (16)
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In this section

Filter By

  • Principal Investigator / Faculty (6)

Organizations

  • Center for Computational and Genomic Medicine (16)
  • Center for Applied Genomics (8)
  • Department of Pathology and Laboratory Medicine (7)
  • Department of Biomedical and Health Informatics (6)
  • Center for Data-Driven Discovery in Biomedicine (5)
  • Department of Surgery (5)
  • Department of Pediatrics (4)
  • PolicyLab (4)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (4)
  • Center for Childhood Cancer Research (3)
  • Center for Injury Research and Prevention (3)
  • Center for Single Cell Biology (3)
  • Division of Allergy and Immunology (3)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (3)
  • Center for Applied Genomics Laboratory (2)
  • Center for Mitochondrial and Epigenomic Medicine (2)
  • Center for Spatial and Functional Genomics (2)
  • Division of Cancer Pathobiology (2)
  • Division of Cardiology (2)
  • Division of Emergency Medicine (2)
  • Division of Neonatology (2)
  • Division of Neurology (2)
  • Division of Neurosurgery (2)
  • Division of Plastic, Reconstructive and Oral Surgery (2)
  • Grant Laboratory (2)
  • Roberts Individualized Medical Genetics Center (2)
  • Spatial and Functional Genomics Research Affinity Group (2)
  • Thomas-Tikhonenko Laboratory (2)
  • Wells Laboratory (2)
  • Akizu Laboratory (1)
  • Bailis Laboratory (1)
  • Blobel Laboratory (1)
  • Brain-Gene-Development Lab (1)
  • Cancer Immunotherapy (CAR-T) (1)
  • Center for Autism Research (1)
  • Center for Pediatric Heart Valve Disorders (1)
  • Center for Violence Prevention (1)
  • Choi Laboratory (1)
  • CHOP Cardiovascular Institute (1)
  • Clinical Futures (1)
  • Comprehensive Bone Marrow Failure Center (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Human Genetics (1)
  • Division of Infectious Diseases (1)
  • Division of Nephrology (1)
  • Division of Orthopaedic Surgery (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • eMERGE (1)
  • High Throughput Sequencing Core (1)
  • Jolley Laboratory (1)
  • Lefebvre Laboratory (1)
  • Leukodystrophy Center of Excellence (1)
  • Liao Laboratory (1)
  • Lifespan Brain Institute (1)
  • Lin Laboratory (1)
  • Minds Matter Concussion Program (1)
  • Mir Laboratory (1)
  • Nah-Cederquist Laboratory (1)
  • Romberg Laboratory (1)
  • Single Cell Technology Core (1)
  • Tasian Laboratory (1)
  • Thyroid Center (1)
  • Translational Research Program in Pediatric Orthopaedics (1)
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