Results for RAS

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Thomas De Raedt, PhD
Thomas De Raedt

Dr. De Raedt researches pediatric high grade glioma development and aims to understand the involvement of crucial pathways. He investigates pathway interaction, and explores ways to develop therapies through analyzing human tumors, performing cellular studies, and developing accurate mouse models. This allows Dr. De Raedt and his team to perform novel pre-clinical studies that can lead to clinical trials.

E-mail:
deraedtt [at] chop.edu
Aime T. Franco, PhD
Aime T. Franco

Dr. Franco researches the molecular basis of the differences between pediatric and adult onset thyroid cancer. She aims to understand how the tumor microenvironment impacts disease progression and response to therapy.

E-mail:
francoa1 [at] chop.edu
Elizabeth J.K. Bhoj, MD PhD
Elizabeth J.K. Bhoj

Dr. Bhoj's genetics research aims to discover new human disease genes, their mechanisms, and potential targeted therapies. In addition to ongoing gene discovery efforts, Dr. Bhoj focuses on three novel genes that lead to pediatric neurologic dysfunction: TBC1 domain-containing kinase, Histone 3.3 (H3F3A and H3F3B), and MAP4K4.

E-mail:
bhoje [at] chop.edu

In the News: Novel Genetic Disorder, ‘Peanut Patch,’ Neonatal Outcomes, Seed Grants

Published on
May 12, 2023
in Cornerstone Blog
In the News: Novel Disorder, ‘Peanut Patch,’ Neonatal Outcomes, Seed Grants
Learn about a novel disorder caused by rare genetic variants, the importance of global neonatal outcomes, and more, in this week’s edition of In the News.

CAR Student Alumni Stories: Jaclin Boorse, MEd

Published on
Jan 26, 2023
in
CAR Student Alumni Stories: Jaclin Boorse, MEd
Learn more about CAR Student Alumni, Jaclin Boorse, MEd.

Snapshot Science: Does Cabozantinib Treat Plexiform Neurofibromas in Neurofibromatosis Type 1?

Published on
Feb 26, 2021
in Cornerstone Blog
Snapshot Science: Does Cabozantinib Treat Plexiform Neurofibromas?
Data from a phase-2 study show that cabozantinib effectively treats plexiform neurofibromas in patients with neurofibromatosis type 1.

In the News: 22q, Mentoring Award, Neonatal E. coli, Gene Therapy, Siegel Award

Published on
Nov 20, 2020
in Cornerstone Blog
In the News
This week in the news: New awards for our scientists and findings for antibiotic stewardship, gene therapy, and 22q11.2 deletion syndrome.

John Maris, MD, Receives National Cancer Institute Outstanding Investigator Award

Published on
Feb 26, 2018
in Cornerstone Blog
John M. Maris, MD
John Maris, MD, distinguished neuroblastoma researcher at CHOP, received the the National Cancer Institute's prestigious Outstanding Investigator Award.

Researchers Pinpoint Mutations in Relapsed Neuroblastoma

Published on
Jun 30, 2015
in Cornerstone Blog
An international collaboration of researchers has identified several progressive series of mutations that occur in tumor cells responsible for aggressive subsets of neuroblastoma that relapse after chemotherapy.

De Raedt Laboratory

De Raedt Laboratory

Research in the De Raedt Lab centers on pediatric high-grade glioma development and aims to understand the involvement of crucial pathways that drive these pediatric brain tumors.

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