The human genome provides a precise, biological blueprint of life. To implement this blueprint correctly, the genome must be read with great precision, but it's impossible for this process to be completely error-free. Mistakes during transcription - random errors in how DNA sequences are copied for a gene to be expressed - can happen any time in any number of ways.
Synapses were firing throughout the conference room in the Colket Translational Research Building as attendees at the 2017 Research Institute Scientific Symposium held May 2 learned about their colleagues' intriguing research endeavors. The four sessions' themes aligned smartly with the Research Institute's strategic planning process and overall mission of the Children's Hospital of Philadelphia.
A team led by CHOP's Marni J. Falk, MD, has expanded next-generation gene tools designed to sequence nuclear DNA to analyze a separate source of DNA - that found within mitochondria. Mitochondria are key suppliers of the energy needed for the multiple functions of our cells.