Dr. Marks investigates the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles; the assembly, delivery and function of their contents; and how these processes are impacted by genetic diseases.
Cell biologist Michael Marks, PhD, studies strange, specific organelles that are only found in certain cell types in our bodies. By dissecting the ways these lysosome-related organelles are assembled, he has gained novel insights into how these mechanisms are thwarted in a rare genetic disease called Hermansky-Pudlak syndrome (HPS). The American Association for the Advancement of Science (AAAS) honored his
The Marks Lab aims to dissect the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles and the assembly, delivery, and function of their contents, and to understand how these processes are impacted by genetic diseases. The lab focuses on processes of importance to the pigmentary, immune, and hemostasis systems, with broad application to understanding organelle biogenesis, signaling, and function within the endolysosomal system.