Dr. Shih studies the metabolic interplay between cell types within the neurovascular unit during stroke to develop effective, novel mitochondrial-directed therapeutics to improve post-stroke disability. She works with small and large animal models of childhood arterial ischemic stroke.
Using translational approaches that encompass genomic studies, biomarker development, disease modeling, natural history studies, and clinical trials, Dr. Vanderver seeks to improve the quality of life and lifespan of individuals living with leukodystrophies or heritable disorder of myelin. She leads the Leukodystrophy Center of Excellence at Children's Hospital of Philadelphia.
Dr. Ichord participates in multiple research projects within Children’s Hospital of Philadelphia and in collaboration with other stroke investigators. Dr. Ichord is especially interested in better understanding the effect of stroke on complex brain function, such as thinking and learning, and developing new strategies to promote recovery and rehabilitation.
Dr. Goldberg's research program focuses on investigating cerebral cortical circuit function and dysfunction in neurodevelopmental disorders. Using a variety of research techniques, Dr. Goldberg has a specific research interest in the workings of neuron subtype called GABAergic inhibitory interneuron and the role of interneuron dysfunction in disease.
Dr. Ortiz-Gonzalez is a physician-scientist specializing in pediatric neurogenetics. Her clinical work focuses on finding a unifying genetic diagnosis for children with rare neurodevelopmental disorders. Her research is informed by her patients and focuses on understanding how genetic changes, in particular those affecting mitochondrial function, cause disease so we can develop better treatments for these children in the future.
Dr. Licht is the director of the Wolfson Family Laboratory for Clinical and Biomedical Optics. His research focuses on the development and use of novel noninvasive optical devices to probe cerebrovascular hemodynamics and physiology in vivo. These devices are used in clinical and preclinical studies to discover the timing and causes of brain injury during care.
Dr. Ahrens-Nicklas works to understand why patients with inherited biochemical disorders often suffer severe, untreatable neurologic and cardiac symptoms. She strives to elucidate the link between biochemistry and network excitability, in order to drive new approaches to therapy.