Dr. Grinspan's research program focuses on oligodendrocytes, cells of the central nervous system that synthesize the myelin sheath required for transmission of nervous impulses. Her research seeks to understand the signaling pathways that regulate oligodendrocyte maturation and how they are perturbed in diseases such as multiple sclerosis, HIV, and perinatal white matter injury.
New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders—complex conditions with severe energy deficiency for which no proven effective treatments exist. Future clinical research is needed to explore whether the drug, cysteamine bitartrate, will meaningfully benefit patients.
Physician-researchers from the Cardiac Center at Children’s Hospital of Philadelphia (CHOP) presented new findings on pediatric cardiovascular disease at the American College of Cardiology’s 67th Annual Scientific Session & Expo 2018 in Orlando, Fla.
The Research Institute's commitment to cultivating and producing strong scientific research is grounded in the diverse mix of experiences, talents, and perspectives that our researchers contribute to our success.
"Diversity has long been a key driver of achievement at Children's Hospital of Philadelphia's Research Institute, particularly when it comes to innovation and performing more accurate and inclusive research," wrote Bryan
Some of the neurological and psychiatric complications associated with HIV may be side effects of the medications that control the virus, and not caused by the virus itself, according to a new study from researchers at The Children’s Hospital of Philadelphia and the University of Pennsylvania.
Phyllis A. Dennery, MD, FAAP, an internationally prominent neonatologist and researcher at The Children's Hospital of Philadelphia, has been elected to the prestigious Institute of Medicine (IOM). Dr. Dennery is the chief of the Division of Neonatology and Newborn Services at Children's Hospital and holds the Werner and Gertrude Henle Endowed Chair in Pediatrics.
At a recent event in Cherry Hill, N.J., longtime CHOP researcher Judith Grinspan, PhD, received the "Professional Impact Award" from the Greater Delaware Valley Multiple Sclerosis Society. Dr. Grinspan has spent more than 25 years examining how multiple sclerosis damages the nervous system,
The Grinspan Lab focuses on oligodendrocytes, cells of the central nervous system that synthesize the myelin sheath required for transmission of nervous impulses. Failure of myelination results in motor and cognitive deficits. The lab’s studies seek to understand the signaling pathways that regulate oligodendrocyte maturation and how they are perturbed in diseases such as multiple sclerosis, HIV, and perinatal white matter injury.