Dr. Grinspan's research program focuses on oligodendrocytes, cells of the central nervous system that synthesize the myelin sheath required for transmission of nervous impulses. Her research seeks to understand the signaling pathways that regulate oligodendrocyte maturation and how they are perturbed in diseases such as multiple sclerosis, HIV, and perinatal white matter injury.
Using translational approaches that encompass genomic studies, biomarker development, disease modeling, natural history studies, and clinical trials, Dr. Vanderver seeks to improve the quality of life and lifespan of individuals living with leukodystrophies or heritable disorder of myelin. She leads the Leukodystrophy Center of Excellence at Children's Hospital of Philadelphia.
For some patients, Children's Hospital of Philadelphia is more than just the place they visited for check-ups, MRI's, and medical tests: It's the spark of inspiration that encouraged them to study medicine, science, or research and kick-start a career in healthcare. As these students prepare to start college and secure financial aid this year, the Demyelinating Disease team in the
A special space is open on the walls of Adeline Vanderver, MD's, new office for a framed collage of "Commander" Massimo "Mo" Damiani, a toddler wearing an orange jumpsuit who looks ready to join a NASA astronaut team. Dr. Vanderver, a child neurologist and geneticist, helped to pinpoint his rare subtype of leukodystrophy, a group of inherited degenerative diseases that
Some of the neurological and psychiatric complications associated with HIV may be side effects of the medications that control the virus, and not caused by the virus itself, according to a new study from researchers at The Children’s Hospital of Philadelphia and the University of Pennsylvania.
At a recent event in Cherry Hill, N.J., longtime CHOP researcher Judith Grinspan, PhD, received the "Professional Impact Award" from the Greater Delaware Valley Multiple Sclerosis Society. Dr. Grinspan has spent more than 25 years examining how multiple sclerosis damages the nervous system,
The Grinspan Lab focuses on oligodendrocytes, cells of the central nervous system that synthesize the myelin sheath required for transmission of nervous impulses. Failure of myelination results in motor and cognitive deficits. The lab’s studies seek to understand the signaling pathways that regulate oligodendrocyte maturation and how they are perturbed in diseases such as multiple sclerosis, HIV, and perinatal white matter injury.