Results for Monogenic Diabetes

1 - 8 of 8

Dr. Pinney investigates the molecular mechanisms that link an adverse intrauterine milieu to the development of diabetes and obesity later in life. Specifically, she is researching how intrauterine growth restriction, gestational diabetes and in utero exposure to environmental toxicants contribute to the development of diabetes and obesity in offspring.

E-mail:

pinneys [at] chop.edu

Karla F. Leavens, MD, PhD

Dr. Leavens uses stem cell-derived beta cells to model pediatric beta cell disease, including monogenic diabetes and congenital hyperinsulinism. The goal of her studies is to better understand and develop novel therapeutics to treat these diseases.

E-mail:

leavensk [at] chop.edu

Diva D. De León-Crutchlow, MD, MSCE

Dr. De Leon-Crutchlow’s translational research program focuses on examining the pathophysiology of disorders of insulin regulation, identifying novel therapeutic targets, and developing new therapies for these conditions. The program approach includes patient-oriented research and bench research employing mouse models and primary islet cultures.

E-mail:

deleon [at] chop.edu

Collaborators Uncover Genetic Basis of Very Early Onset Inflammatory Bowel Disease

Published on

Apr 3, 2019

in Cornerstone Blog

Marcella Devoto, PhD; Judith Kelsen, MD; and colleagues are using technologies like whole exome sequencing to uncover the genetic basis of very early onset inflammatory bowel disease.

In the News: Neuroscience of Driving, ASD Reward Circuitry, Orthopaedics Meeting, Diva De Leon-Crutchlow

Published on

Jun 29, 2018

in Cornerstone Blog

This week's roundup of research headlines at CHOP is all about making connections.

Diva D. De León-Crutchlow, MD, Named Chief of Endocrinology and Diabetes

Published on

Jun 25, 2018

in Press Releases

Diva D. De León-Crutchlow, MD, MSCE, will assume the role as Chief of the Division of Endocrinology and Diabetes at Children’s Hospital of Philadelphia (CHOP), effective July 1, 2018.

Pinney Laboratory

Dr. Pinney’s research focuses on determining the molecular mechanisms that link an adverse intrauterine milieu to the development of diabetes and obesity later in life.

Center for Spatial and Functional Genomics

The Center for Spatial and Functional Genomics is focused on uncovering the correct functional context of variants identified by genome-wide association studies in order to translate these discoveries into meaningful benefits for pediatric care.