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Results for Mitochondrial Function and Metabolic Disease

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Itzhak Nissim, PhD

Dr. Nissim is a biochemist and a pioneer in the application of stable isotopes, mass spectrometry, and nuclear magnetic resonance to study metabolome and fluxome and their coupling to genome in normal and disease states. His long-standing interest focuses on understanding the cause, mechanisms, and outcome of metabolic disorders.

E-mail:
nissim [at] chop.edu
Liming Pei, PhD
Liming Pei

Dr. Pei's research aims to understand the molecular underpinnings of cardiac remodeling associated with cardiomyopathy and heart failure. He is particularly interested in two areas of cardiac remodeling: metabolic reprogramming, and secretion of heart-derived hormones to communicate with other organs.

E-mail:
peil [at] chop.edu
Will Bailis, PhD
Will Bailis

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

E-mail:
bailisw [at] chop.edu
Daniel P. Kelly, MD
Daniel P. Kelly

Dr. Kelly’s research career began with deciphering the genetic basis of inborn errors in metabolism in children, followed by a series of breakthrough discoveries relevant to the diagnosis and treatment of common forms of heart failure in the general population.

E-mail:
dankelly [at] pennmedicine.upenn.edu

Understanding Mitochondrial Adaptation: Q&A With Diversity Fellow Arnold Olali, PhD

Published on
Dec 27, 2022
in Cornerstone Blog
Q&A With Diversity Fellow Arnold Olali, PhD
Featured Diversity Fellow Arnold Olali, PhD, is focused on understanding how mitochondria affect overall health.

Researchers Aim to Develop Noninvasive Methods to Diagnose Mitochondrial Diseases

Published on
Nov 9, 2022
in Cornerstone Blog
Researchers Study Diagnostic Methods for Mitochondrial Diseases
A U.S. Department of Defense grant will support CHOP researchers in their study of noninvasive methods to diagnose mitochondrial diseases.

‘The future of research benefits from diversity:’ Faculty Spotlight With Liming Pei, PhD

Published on
Oct 31, 2022
in Cornerstone Blog
Faculty Spotlight With Liming Pei, PhD
Liming Pei, PhD, studies how different organs react to energy cues and communicate with each other.

In the News: Mitochondrial Disease, ALL, Type 2 Diabetes, Sleep Apnea

Published on
Sep 16, 2022
in Cornerstone Blog
In the News
This week’s In the News highlights research on mitochondrial disease, acute lymphoblastic leukemia, type 2 diabetes, and sleep apnea.

In The News: Kidney Innovation Center, Adolescent Concussion, Beta Thalassemia, Exercise Intolerance

Published on
Sep 2, 2022
in Cornerstone Blog
Our Scientists’ Research Highlighted In the News
Learn about novel findings from our Children’s Hospital of Philadelphia researchers.

CHOP Research Institute Scientific Symposium: Harnessing the Immune Response

Published on
Jun 2, 2022
in Cornerstone Blog
Scientific Symposium 2022: Harnessing the Immune Response
CHOP and Penn researchers discussed the latest findings about the mechanisms of immunity at the CHOP Research Institute 2022 Scientific Symposium.
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In this section

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  • Principal Investigator / Faculty (4)

Organizations

  • Center for Mitochondrial and Epigenomic Medicine (17)
  • Mitochondrial Medicine (11)
  • Department of Pathology and Laboratory Medicine (6)
  • Center for Injury Research and Prevention (4)
  • Center for Applied Genomics (3)
  • Department of Anesthesiology and Critical Care Medicine (3)
  • Department of Pediatrics (3)
  • Center for Childhood Cancer Research (2)
  • Center for Spatial and Functional Genomics (2)
  • Division of Infectious Diseases (2)
  • Friedreich’s Ataxia Center of Excellence (2)
  • Minds Matter Concussion Program (2)
  • PolicyLab (2)
  • Wallace Laboratory (2)
  • Comprehensive Bone Marrow Failure Center (1)
  • Cystic Fibrosis-Related Diabetes Research Program (1)
  • Department of Biomedical and Health Informatics (1)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (1)
  • Division of Allergy and Immunology (1)
  • Division of Developmental and Behavioral Pediatrics (1)
  • Division of Endocrinology and Diabetes (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Hematology (1)
  • Division of Human Genetics (1)
  • Division of Nephrology (1)
  • Division of Neurology (1)
  • Division of Oncology (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • Hamilton Laboratory (1)
  • Inflammatory Bowel Disease Center (1)
  • Office of Academic Training and Outreach Programs (1)
  • Pei Laboratory (1)
  • Penn-CHOP Kidney Innovation Center (1)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (1)
  • Romberg Laboratory (1)
  • Wolfson Family Laboratory for Clinical and Biomedical Optics (1)

In this section

Filter By

  • Principal Investigator / Faculty (4)

Organizations

  • Center for Mitochondrial and Epigenomic Medicine (17)
  • Mitochondrial Medicine (11)
  • Department of Pathology and Laboratory Medicine (6)
  • Center for Injury Research and Prevention (4)
  • Center for Applied Genomics (3)
  • Department of Anesthesiology and Critical Care Medicine (3)
  • Department of Pediatrics (3)
  • Center for Childhood Cancer Research (2)
  • Center for Spatial and Functional Genomics (2)
  • Division of Infectious Diseases (2)
  • Friedreich’s Ataxia Center of Excellence (2)
  • Minds Matter Concussion Program (2)
  • PolicyLab (2)
  • Wallace Laboratory (2)
  • Comprehensive Bone Marrow Failure Center (1)
  • Cystic Fibrosis-Related Diabetes Research Program (1)
  • Department of Biomedical and Health Informatics (1)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (1)
  • Division of Allergy and Immunology (1)
  • Division of Developmental and Behavioral Pediatrics (1)
  • Division of Endocrinology and Diabetes (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Hematology (1)
  • Division of Human Genetics (1)
  • Division of Nephrology (1)
  • Division of Neurology (1)
  • Division of Oncology (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • Hamilton Laboratory (1)
  • Inflammatory Bowel Disease Center (1)
  • Office of Academic Training and Outreach Programs (1)
  • Pei Laboratory (1)
  • Penn-CHOP Kidney Innovation Center (1)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (1)
  • Romberg Laboratory (1)
  • Wolfson Family Laboratory for Clinical and Biomedical Optics (1)
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