Results for Mitochondrial Function and Metabolic Disease

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Itzhak Nissim, PhD

Dr. Nissim is a biochemist and a pioneer in the application of stable isotopes, mass spectrometry, and nuclear magnetic resonance to study metabolome and fluxome and their coupling to genome in normal and disease states. His long-standing interest focuses on understanding the cause, mechanisms, and outcome of metabolic disorders.

E-mail:
nissim [at] chop.edu
Liming Pei, PhD
Liming Pei

Dr. Pei's research aims to understand the molecular underpinnings of cardiac remodeling associated with cardiomyopathy and heart failure. He is particularly interested in two areas of cardiac remodeling: metabolic reprogramming, and secretion of heart-derived hormones to communicate with other organs.

E-mail:
peil [at] chop.edu

Preclinical Study Shows Combination of Vitamins, Supplements May Benefit Mitochondrial Disease

Published on
Mar 26, 2021
in Cornerstone Blog
Trio of Supplements May Be Effective in Mitochondrial Disease
A combination of vitamins and supplements appears to be beneficial in treating mitochondrial disease, which has no approved treatment.

In the News: COVID Testing, Immunometabolism, Autistic Drivers, Neighborhoods and Sleep

Published on
Feb 5, 2021
in Cornerstone Blog
In the News
Discover new findings about COVID-19 testing before surgery, the link between mitochondria and autism, and how neighborhoods affect sleep.

Out of This World: CHOP Researchers Help Elucidate Health Effects of Spaceflight

Published on
Nov 25, 2020
in Cornerstone Blog
Out of This World: CHOP Researchers Help Elucidate Health Effects of Spaceflight
Researchers at CHOP collaborated with NASA and other institutions to determine possible mechanisms behind the health effects of spaceflight.

In The News: Football Concussions, Early Intervention Referrals, Mitochondrial DNA, Panama TV, ‘Research in Motion,’ Bone Marrow Failure

Published on
Oct 23, 2020
in Cornerstone Blog
In the News
This week’s roundup features research reinforcing the need for better universal surveillance for developmental delays and increased access to early intervention. This and more In The News.

In the News: MtDNA Gene Expression, Carousel Ball, NIH Innovator Awards, NKAP-related Syndrome, Discussing Youth Suicide

Published on
Oct 18, 2019
in Cornerstone Blog
CHOP Research In the News
This week, researchers elucidate mechanisms of mitochondrial DNA mutations, identify a new neurodevelopmental syndrome, and more.

In the News: Driving and Autism, Epilepsy Learning System, Youth-onset Diabetes, Mitochondrial Research Award, MicroRNA and Obesity, Well-being Measures

Published on
Jun 28, 2019
in Cornerstone Blog
CHOP Research In the News
As summer heats up, our scientists are making headlines with their discoveries in the fields of diabetes, autism, and obesity research.

An Existing Drug May Have Therapeutic Potential in Mitochondrial Disease

Published on
Feb 26, 2019
in Press Releases
New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders—complex conditions with severe energy deficiency for which no proven effective treatments exist. Future clinical research is needed to explore whether the drug, cysteamine bitartrate, will meaningfully benefit patients.

Ashkenazi Jewish Founder Mutation Identified in Leigh Syndrome

Published on
Nov 15, 2018
in Press Releases
In Newly Recognized Cause of a Pediatric Mitochondrial Disease, CHOP Researchers Find Long-awaited Answers for Parents
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