The Silverman Lab investigates early-life modifiable factors influencing the development and function of the immune system and harnesses these factors to prevent autoimmune diabetes (T1D). The lab discovered that the major histocompatibility complex class II E molecule prevents T1D by shaping the intestinal microbiota early in life. These protective early-life microbes then educate the immune system to prevent autoimmunity.
Looking for help with sequencing and analytics to advance your project? The CHOP Microbiome Center is the sequencing and analytical resource of the PennCHOP Microbiome Program, providing end-to-end solutions for microbiome research.