Dr. Poncz investigates the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes are the central foci of his laboratory work. Many of his studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.
Dr. Lambert's research focuses on understanding the mechanisms of inherited and acquired thrombocytopenia in pediatric patients. Using clinical translational methods to link discovery in rare platelet disorders with optimizing next-generation sequencing for clinical practice, she has been involved in the Undiagnosed Disease Network Program and the Frontier Program in Immune Dysregulation, incorporating genetics of platelet disorders and immunohematology.
Dr. Marks investigates the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles; the assembly, delivery and function of their contents; and how these processes are impacted by genetic diseases.
Looking at a scientific problem from new and different perspectives is what research is all about, which is why Children's Hospital of Philadelphia's Research Institute is dedicated to cultivating a more diverse workforce. "We value diversity within our research community and it is undoubtedly part of what makes us successful," wrote Bryan A. Wolf, MD, PhD, Chief Scientific Officer and Director
The Marks Lab aims to dissect the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles and the assembly, delivery, and function of their contents, and to understand how these processes are impacted by genetic diseases. The lab focuses on processes of importance to the pigmentary, immune, and hemostasis systems, with broad application to understanding organelle biogenesis, signaling, and function within the endolysosomal system.
The Gadue Laboratory studies human pancreatic and hematopoietic development and associated diseases using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells. The lab has devoted much of its research efforts on directed differentiation and CRISPR-based genome engineering of stem cells and is using this system for the study and development of treatments for diabetes and blood disorders.