Dr. Grupp develops and conducts preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric immunotherapy trials, and in the manufacture and use of cellular therapeutics in preclinical, good manufacturing practices, and clinical trial settings. Dr. Grupp leads most CTL019 (CD19 CAR) clinical trials, and his colleagues are the global leaders in highly active CAR T cell therapy.
When the immune system inappropriately destroys blood cells, in a relatively rare group of diseases called autoimmune cytopenias, children may suffer for years with anemia, uncontrolled bleeding, and vulnerability to infections, while their parents struggle to find a diagnosis.
The Children's Hospital of Philadelphia's groundbreaking leukemia research was on display at the recent American Society of Hematology (ASH) Annual Meeting. Held in New Orleans, the ASH Annual Meeting brought together approximately 20,000 researchers, clinicians, and industry representatives, with data from more than 5,300 abstracts presented.