Results for Intellectual and Developmental Disabilities

Dr. Blum is the principal investigator for the national multi-site Developmental-Behavioral Pediatric Research Network (DBPNet). Recent studies in the network relate to the assessment and treatment of attention deficit/ hyperactivity disorder (ADHD) and of autism spectrum disorders (ASD).

Dr. Robinson has a longstanding research interest in the function and regulation of brain glutamate transport under physiologic and pathologic conditions.

Dr. Marsh's research program focuses on understanding how changes in brain development lead to epilepsy, intellectual disability, and autism. He combines molecular and physiological tools in mouse models to ask questions about the interaction of normal development with single gene mutations to determine how the brain responds to perturbations in development.

Dr. Lefebvre investigates the genetic mechanisms that generate the diversity of cell types composing the body. Her emphasis is on deciphering how proteins called SOX transcription factors specify stem cells and highly specialized cells in the skeleton, how changes in these factors cause skeletal diseases, and how these factors also control other processes, including brain development and intellectual disability diseases.

Research by Dr. Yerys focuses on the development of cognitive and neural mechanisms that support adaptive behavior in children with neurodevelopmental disorders.

Dr. Coulter conducts physiological studies examining mechanisms of epilepsy. His research centers on injury-induced epilepsies as well as genetically-induced epilepsy, autism, and developmental intellectual disabilities.

Dr. Bhoj's genetics research aims to discover new human disease genes, their mechanisms, and potential targeted therapies. In addition to ongoing gene discovery efforts, Dr. Bhoj focuses on three novel genes that lead to pediatric neurologic dysfunction: TBC1 domain-containing kinase, Histone 3.3 (H3F3A and H3F3B), and MAP4K4.

Dr. Takano's research focuses on basic epilepsy and related neuroscience research centered on advanced optical imaging techniques such as fluorescence lifetime imaging and two-photon microscopy; and application of micro- and nanotechnology like graphene transparent electrode to functional cellular imaging.