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Results for Hematopoiesis

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Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu
Christopher S. Thom, MD, PhD
Christopher S. Thom

Dr. Thom uses computational and cellular approaches to understand genetic determinants of hematopoiesis. Dr. Thom aims to harness related insights to improve in vitro blood cell production from induced pluripotent stem cells.

E-mail:
thomc [at] chop.edu
Julia T. Warren, MD, PhD
Julia T. Warren

Dr. Warren studies normal and aberrant hematopoiesis, with a special interest in granulopoiesis. Her research aims to understand the pathogenesis of severe congenital neutropenia and its risk for malignant transformation. She has a clinical interest in neutropenia syndromes including clinical trials.

E-mail:
warrenjt [at] chop.edu
Carolyn A. Felix, MD
Carolyn A. Felix

Dr. Felix uses molecular, biochemical, cellular and in vivo methods to investigate the pathobiology of leukemias with KMT2A (MLL) translocations. Leukemias with these translocations affect infants and young children or occur as a complication of type II topoisomerase (TOP2) poison chemotherapies used for anti-cancer treatment. She aims to develop better treatment and prevention approaches for these leukemias, which have a poor prognosis.

E-mail:
felix [at] chop.edu
Timothy S. Olson, MD, PhD
Timothy S. Olson Headshot

Dr. Olson aims to improve diagnostics and treatment of bone marrow failure (BMF) syndromes, and to improve clinical hematopoietic stem cell transplantation (HSCT) outcomes. He conducts clinical trials of HSCT for non-malignant hematologic diseases. His laboratory explores both basic and translational research focused on genomics of BMF and the impact of BMF on hematopoietic niche function during HSCT.

E-mail:
olsont [at] chop.edu
Paul Gadue, PhD
Paul Gadue

Dr. Gadue studies cell fate decisions, focusing on endoderm and mesoderm specification using human embryonic stem (ES) cells and induced pluripotent stem (iPS).

E-mail:
gaduep [at] chop.edu
Sarah Adams
Sarah Adams

Adams joined the Kurre Laboratory in 2022 and is working to understand clonal hematopoiesis in Fanconi Anemia to advance understanding of and treatments for pediatric hematological disorders.

E-mail:
adamss7 [at] chop.edu
Stephanie N. Hurwitz, MD, PhD
Stephanie N. Hurwitz

Stephanie Hurwitz, MD, PhD, is a research fellow focused on improving understanding of the molecular biogenesis and functions of extracellular vesicles in physiologic and regenerative hematopoietic stem cell biology.

E-mail:
hurwitzs [at] chop.edu
Suying Liu, BS
Suying Liu

Suying Liu leads the research project into the clonal restraints of hematopoiesis in an inherited bone marrow failure syndrome, Fanconi Anemia, to promote better understanding and treatment of pediatric hematological disorders.

E-mail:
lius10 [at] chop.edu

Faculty Spotlight: Blood Biology Meets Genetics With Christopher Thom, MD, PhD

Published on
Dec 20, 2022
in Cornerstone Blog
Christopher S. Thom, MD, PhD
Our December Faculty Spotlight scientist, Christopher Thom, MD, PhD, works at the intersection of genetics, blood biology, and cellular therapeutics.
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In this section

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  • Principal Investigator / Faculty (6)
  • Researcher / Lab Personnel (3)

Organizations

  • Division of Oncology (4)
  • Division of Hematology (3)
  • Normal and Malignant Hematopoiesis Research Affinity Group (3)
  • Center for Applied Genomics (2)
  • Department of Pediatrics (2)
  • Division of Neonatology (2)
  • Comprehensive Bone Marrow Failure Center (1)
  • Cystic Fibrosis-Related Diabetes Research Program (1)
  • Department of Pathology and Laboratory Medicine (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Mitochondrial Medicine (1)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (1)
  • Romberg Laboratory (1)

In this section

Filter By

  • Principal Investigator / Faculty (6)
  • Researcher / Lab Personnel (3)

Organizations

  • Division of Oncology (4)
  • Division of Hematology (3)
  • Normal and Malignant Hematopoiesis Research Affinity Group (3)
  • Center for Applied Genomics (2)
  • Department of Pediatrics (2)
  • Division of Neonatology (2)
  • Comprehensive Bone Marrow Failure Center (1)
  • Cystic Fibrosis-Related Diabetes Research Program (1)
  • Department of Pathology and Laboratory Medicine (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Mitochondrial Medicine (1)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (1)
  • Romberg Laboratory (1)
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