Results for Hematopoiesis

The Gadue Laboratory studies human pancreatic and hematopoietic development and associated diseases using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells. The lab has devoted much of its research efforts on directed differentiation and CRISPR-based genome engineering of stem cells and is using this system for the study and development of treatments for diabetes and blood disorders.

The Rivella Laboratory investigates erythropoiesis, iron metabolism and inflammation and develops new therapeutics for the cure of hemoglobinopathies.

The Tan Laboratory studies the fundamental question of transcriptional regulation during normal development and disease. It involves a complex interplay of multiple transcription factors and epigenetic factors in the context of a three-dimensional chromosomal environment. Using experimental genomics and computational modeling, the lab has been studying transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

The Blobel Lab investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin, gearing its basic science discoveries toward genetic and epigenetic treatment modalities.

The Behrens Lab is interested in the pathogenesis and treatment of cytokine storm syndromes, including the hemophagocytic syndromes Hemophagocytic Lymphohistiocytosis (HLH) and Macrophage Activation Syndrome (MAS).  These are uniquely pediatric immunologic conditions that result in severe systemic inflammation and death if unrecognized and untreated.