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Results for Hematopoiesis

1 - 10 of 21

Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu
Christopher S. Thom, MD, PhD
Christopher S. Thom

Dr. Thom uses computational and cellular approaches to understand genetic determinants of hematopoiesis. Dr. Thom aims to harness related insights to improve in vitro blood cell production from induced pluripotent stem cells.

E-mail:
thomc [at] chop.edu
Paul Gadue, PhD
Paul Gadue

Dr. Gadue studies cell fate decisions, focusing on endoderm and mesoderm specification using human embryonic stem (ES) cells and induced pluripotent stem (iPS).

E-mail:
gaduep [at] chop.edu
Carolyn A. Felix, MD
Carolyn A. Felix

Dr. Felix uses molecular, biochemical, cellular and in vivo methods to investigate the pathobiology of leukemias with KMT2A (MLL) translocations. Leukemias with these translocations affect infants and young children or occur as a complication of type II topoisomerase (TOP2) poison chemotherapies used for anti-cancer treatment. She aims to develop better treatment and prevention approaches for these leukemias, which have a poor prognosis.

E-mail:
felix [at] chop.edu
Timothy S. Olson, MD, PhD
Timothy S. Olson Headshot

Dr. Olson aims to improve diagnostics and treatment of bone marrow failure (BMF) syndromes, and to improve clinical hematopoietic stem cell transplantation (HSCT) outcomes. He conducts clinical trials of HSCT for non-malignant hematologic diseases. His laboratory explores both basic and translational research focused on genomics of BMF and the impact of BMF on hematopoietic niche function during HSCT.

E-mail:
olsont [at] chop.edu

In the News: Type 1 Diabetes, CZI Grant, Cystic Fibrosis, Mitochondrial Disease

Published on
Sep 3, 2021
in Cornerstone Blog
In the News: Diabetes, CZI Grant, Cystic Fibrosis, Mitochondrial Disease
This week’s In the News highlights two new studies, a new grant, the new director of the Cystic Fibrosis Center, and a physician’s new role.

Meet the 2020 Distinguished Research Trainee Award Recipients

Published on
Feb 11, 2021
in Cornerstone Blog
Meet the 2020 Distinguished Research Trainee Award Recipients
The 2020 Distinguished Research Trainee Award Recipients include trainees from a variety of levels and disciplines.

Exploring Exosome-Mediated Stem Cell Engraftment for Hemoglobinopathies

Published on
May 8, 2019
in Cornerstone Blog
Meghana V. Kashyap, MD
A surgeon-scientist explores exosome-mediated stem cell engraftment as a means to lessen disease severity and enhance quality of life for children with hemoglobinopathies.

Rescuing Mutation May Operate in Bone Marrow Failure

Published on
Nov 19, 2014
in Cornerstone Blog
Bone marrow failure syndromes are rare disorders in which the bone marrow does not produce enough blood cells, increasing the risk for life-threatening bleeding, anemia, and infections.

Alex's Lemonade Stand Foundation Grant Supports CHOP Childhood Cancer Research Project

Published on
Feb 13, 2014
in Cornerstone Blog
One in every 691 babies in the U.S. is born with Down syndrome, according to the National Down Syndrome Society, and have a predisposition for a certain kind of cancer.
1 - 10 of 21

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In this section

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  • Principal Investigator / Faculty (5)

Organizations

  • Division of Oncology (4)
  • Division of Hematology (3)
  • Normal and Malignant Hematopoiesis Research Affinity Group (3)
  • Center for Applied Genomics (2)
  • Comprehensive Bone Marrow Failure Center (1)
  • Cystic Fibrosis-Related Diabetes Research Program (1)
  • Department of Pathology and Laboratory Medicine (1)
  • Department of Pediatrics (1)
  • Division of Neonatology (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Mitochondrial Medicine (1)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (1)
  • Romberg Laboratory (1)

In this section

Filter By

  • Principal Investigator / Faculty (5)

Organizations

  • Division of Oncology (4)
  • Division of Hematology (3)
  • Normal and Malignant Hematopoiesis Research Affinity Group (3)
  • Center for Applied Genomics (2)
  • Comprehensive Bone Marrow Failure Center (1)
  • Cystic Fibrosis-Related Diabetes Research Program (1)
  • Department of Pathology and Laboratory Medicine (1)
  • Department of Pediatrics (1)
  • Division of Neonatology (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Mitochondrial Medicine (1)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (1)
  • Romberg Laboratory (1)
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