Bone disorders exact a considerable toll on human health in both children and adults. Dr. Long seeks to understand the fundamental mechanisms underlying both normal skeletal development and the pathophysiology of bone diseases. His current research includes studies of skeletal stem cells and progenitors, metabolic regulation of bone cells, and the integration of bone and whole-body metabolism.
Dr. Koyama's research focuses on Hereditary Multiple Exostoses (HME), a genetic disorder that causes the development of multiple benign tumors on the surface of the metaphyses of long bones. Based on his extensive knowledge of the normal processes of skeletal development and growth, Dr. Koyama's research aims to clarify the molecular mechanisms of HME formation and growth.
Tom Curran, PhD, FRS, of The Children’s Hospital of Philadelphia Research Institute, contributed to an article in the Journal of Clinical Oncology assessing the efficacy of a drug called vismodegib (Erivedge) in a subgroup of patients with recurrent medulloblastoma.
Eiki Koyama, DDS, PhD and Hyun-Duck Nah, DMD, PhD, from the Children's Hospital of Philadelphia, recently received a grant from the National Institute of Dental & Craniofacial Research to study the development of the TMJ.
A world-renowned cancer investigator at The Children's Hospital of Philadelphia will be honored by the American Association for Cancer Research as it inaugurates the first class of the Fellows of the AACR Academy.
Understanding the mechanisms by which the skeleton forms and grows in healthy babies and children and using this information to uncover the pathogenesis of rare and common musculoskeletal disorders by working with animal models of the diseases.